Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 10/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.44 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499677 | 0.87 | UHRF1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3660321 | 0.87 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9729373 | 0.85 | ACHE (0.46) | ACP3ALDH1A1ACHECYP19A1 | |
| SCHEMBL6510105 | 0.84 | MAPKAPK2 (0.44) | ACP3MAPKAPK2ACHEMAPK14CYP19A1 | |
| SCHEMBL1515743 | 0.80 | ACP3 (0.50) | ACP3ACHE | |
| SCHEMBL3903975 | 0.78 | CYP11B1 (0.44) | MAPKAPK2CYP19A1CYP11B1 | |
| SCHEMBL7394777 | 0.78 | PTGDR2 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3904396 | 0.77 | SLC6A2 (0.42) | ACP3ALDH1A1 | |
| SCHEMBL3908501 | 0.76 | TRPM8 (0.40) | ACP3ALDH1A1ACHE | |
| SCHEMBL27924262 | 0.73 | UHRF1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050080113-A1 | Medicinal compositions | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080113-A1 | Medicinal compositions | TNF, TRAF6, MMP8 | PSEN1 3987/4885PSEN2 4121/4885APH1B 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.