Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3893442 | 0.93 | HTR6 (0.49) | HTR6HTR2AHTR2CDRD2DRD3 | |
| SCHEMBL6509242 | 0.88 | MAOB (0.54) | HTR6HTR2AHTR2CPKMMAOB | |
| Hydrochloric Acid SCHEMBL6504357 | 0.87 | MAOB (0.53) | HTR6HTR2AHTR2CPKMMAOB | |
| SCHEMBL6500345 | 0.85 | MAPT (0.51) | HTR6PKMMAOBMAPTLMNA | |
| SCHEMBL3903162 | 0.81 | MAOB (0.48) | HTR6HTR2AHTR2CDRD2DRD3 | |
| SCHEMBL6505821 | 0.79 | HTR6 (0.47) | HTR6HTR2AHTR2CPKMMAPT | |
| SCHEMBL6502583 | 0.78 | LMNA (0.48) | HTR6HTR2AHTR2CDRD2DRD3 | |
| SCHEMBL6510748 | 0.78 | HTR6 (0.46) | HTR6HTR2AHTR2CDRD2DRD3 | |
| SCHEMBL6500880 | 0.78 | LMNA (0.51) | HTR6DRD2DRD3PKMMAPT | |
| SCHEMBL3894249 | 0.78 | POLB (0.43) | HTR2CPKMMAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014578-A1 | PHENYLSULFONYL COMPOUNDS AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2005-02-17 | — | — | WO | claimed |
| WO-2005014578-A1 | PHENYLSULFONYL COMPOUNDS AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2005-02-17 | — | — | WO | disclosed |