Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | PDE1A | P54750 | 1/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503612 | 0.97 | PDE5A (0.68) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL6502773 | 0.87 | PDE5A (0.73) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL6501252 | 0.86 | PDE5A (0.80) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| Sulfuric Acid SCHEMBL7012672 | 0.85 | PDE5A (0.78) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| Sulfuric Acid SCHEMBL7012675 | 0.83 | PDE5A (0.76) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL6508168 | 0.83 | PDE5A (0.74) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL22066547 | 0.83 | PDE5A (0.80) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL6639437 | 0.83 | PDE5A (0.77) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL6529760 | 0.83 | PDE5A (0.84) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL6641779 | 0.83 | PDE5A (0.81) | PDE5APDE3BPDE3APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050130983-A1 | Pyrrolopyrimidinone derivatives, process for preparation thereof, and method of using and composition comprising them | IN2GEN CO., LTD. (KR) | 2005-06-16 | — | — | US | disclosed |
| US-20050113346-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | WYETH HOLDINGS CORPORATION | 2005-05-26 | — | — | US | disclosed |
| US-6812227-B2 | SULFUR COMPOUNDS SUCH AS 2-((4-BUT-2-YNYLOXY-BENZENESULFONYL)-METHYL-AMINO)-N-HYDROXY-3-METHYL -BUTYRAMIDE, USED AS TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME (TACE) INHIBITORS, FOR PROPHYLAXIS OF RHEUMATIC DISEASES, SEPSIS OR INFLAMMATION | WYETH HOLDINGS CORPORATION | 2004-11-02 | — | — | US | disclosed |
| EP-1144368-B1 | ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | WYETH CORP (US) | 2004-07-14 | — | — | EP | disclosed |
| US-6716833-B2 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, SEPSIS, AIDS, ULCERATIVE COLITIS, MULTIPLE SCLEROSIS, CROHN'S DISEASE AND DEGENERATIVE CARTILAGE LOSS. | WYETH HOLDINGS CORPORATION | 2004-04-06 | — | — | US | disclosed |
| EP-1362858-A1 | Pyrrolopyrimidinone derivates, process of preparation and use | SK Chemicals Co., Ltd. (KR) | 2003-11-19 | — | — | EP | disclosed |
| US-6225311-B1 | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors | AMERICAN CYANAMID COMPANY | 2001-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113346-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | TNF, SI, MMP12 | PDE5A 3957/4885PDE3B 3883/4885PDE3A 3745/4885 |
| US-20050130983-A1 | Pyrrolopyrimidinone derivatives, process for preparation thereof, and method of using and composition comprising them | DHPS, SDHA, FDPS | PDE5A 582/4885PDE3B 330/4885PDE3A 479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.