Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PRKX | P51817 | 1/20 | 0.38 |
| ▸ | NEK4 | P51957 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.38 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5184111 | 0.85 | CYP19A1 (0.61) | CYP19A1MAPK1AKT1FFAR2CYP11B1 | |
| SCHEMBL3907301 | 0.84 | CYP19A1 (0.41) | CYP19A1MAPK1ROCK2GSK3BROCK1 | |
| SCHEMBL1515718 | 0.81 | IDO1 (0.46) | CYP2D6KMT2AALDH1A1MEN1 | |
| SCHEMBL6499767 | 0.78 | CYP3A4 (0.35) | CYP19A1CYP3A4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1515763 | 0.76 | SLC6A3 (0.58) | CYP2D6SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL3658338 | 0.76 | MEN1 (0.46) | CYP19A1CYP3A4CYP2D6SLC6A4CYP2C19 | |
| SCHEMBL2789136 | 0.73 | LTA4H (0.42) | CYP19A1CYP11B1CYP11B2KMT2AMEN1 | |
| SCHEMBL6504970 | 0.73 | CYP19A1 (0.39) | CYP19A1CYP3A4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8309987 | 0.73 | LMNA (0.42) | CYP19A1CYP3A4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14834576 | 0.71 | CYP19A1 (0.42) | CYP19A1MAPK1MAP4K4FFAR2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050080113-A1 | Medicinal compositions | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080113-A1 | Medicinal compositions | TNF, TRAF6, MMP8 | CYP19A1 2827/4885MAPK1 4/4885ROCK2 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.