Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503843 | 0.76 | MAPT (0.48) | HPGDROCK2ROCK1GAAMAPT | |
| SCHEMBL6495876 | 0.75 | HPGD (0.44) | HPGDGAAMAPTTP53EPHX2 | |
| SCHEMBL6502341 | 0.74 | EPHX2 (0.44) | HPGDMAPTTP53EPHX2LMNA | |
| SCHEMBL6494246 | 0.74 | LMNA (0.44) | HPGDROCK2ROCK1MAPTTP53 | |
| SCHEMBL6504802 | 0.73 | HTT (0.55) | HPGDROCK2ROCK1GAAMAPT | |
| SCHEMBL6506747 | 0.73 | CA2 (0.48) | HPGDNPC1ROCK2ROCK1MAPT | |
| SCHEMBL6503028 | 0.73 | PDE10A (0.47) | HPGDNPC1ROCK2ROCK1GAA | |
| SCHEMBL6496500 | 0.72 | HPGD (0.53) | HPGDROCK2ROCK1GAAMAPT | |
| SCHEMBL6501926 | 0.72 | KMT2A (0.45) | HPGDROCK2ROCK1MAPTRAB9A | |
| SCHEMBL6503133 | 0.72 | LMNA (0.56) | HPGDROCK2ROCK1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |