Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496500 | 0.86 | HPGD (0.53) | HTTROCK2ROCK1LMNATP53 | |
| SCHEMBL6503843 | 0.85 | MAPT (0.48) | HTTROCK2ROCK1LMNATP53 | |
| SCHEMBL6495951 | 0.78 | HPGD (0.53) | HTTLMNAMAPTGAAHPGD | |
| SCHEMBL6505651 | 0.77 | HPGD (0.49) | HTTLMNAMAPTGAAHPGD | |
| SCHEMBL13846776 | 0.76 | CA2 (0.69) | LMNAMAPTPOLBGAAPPARG | |
| SCHEMBL6497335 | 0.76 | MEN1 (0.53) | HTTLMNAMAPTPOLBGAA | |
| SCHEMBL6498811 | 0.76 | HPGD (0.48) | HTTROCK2ROCK1LMNATP53 | |
| SCHEMBL2176934 | 0.74 | EPHX2 (0.53) | ROCK2ROCK1TP53MAPTPPARG | |
| SCHEMBL6498700 | 0.74 | HPGD (0.47) | HTTROCK2ROCK1LMNAMAPT | |
| SCHEMBL6503004 | 0.73 | HPGD (0.46) | HTTROCK2ROCK1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |