SCHEMBL6504181

SCHEMBL6504181

CCCc1cn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 4/20 0.45
AGTR2 P50052 4/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6500594 0.95 AGTR1 (0.49) AGTR1AGTR2
SCHEMBL6494354 0.95 AGTR1 (0.43) AGTR1AGTR2
SCHEMBL6492141 0.95 AGTR1 (0.47) AGTR1AGTR2
SCHEMBL6492268 0.95 AGTR1 (0.51) AGTR1AGTR2
SCHEMBL6500485 0.94 AGTR1 (0.42) AGTR1AGTR2
SCHEMBL6491839 0.94 AGTR1 (0.42) AGTR1AGTR2
SCHEMBL6502648 0.94 AGTR1 (0.49) AGTR1AGTR2
SCHEMBL6492105 0.93 AGTR1 (0.43) AGTR1AGTR2
SCHEMBL6490838 0.93 AGTR1 (0.49) AGTR1AGTR2
SCHEMBL6492945 0.93 AGTR1 (0.41) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0073451-B1 CARBAPENAM COMPOUND AND PROCESSES FOR THE PREPARATION THEREOF FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1987-05-13 EP claimed
EP-0073451-A2 Carbapenam compound and processes for the preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1983-03-09 EP claimed
US-4327093-A TREATING INFECTIONS DISEASES, ANTIBACTERIAL ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1982-04-27 US claimed
EP-0010313-A1 3,7-Disubstituted-2- or -3-cephem-4-carboxylic acid compounds, pharmaceutical compositions containing them and processes for the preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1980-04-30 EP claimed
US-6858636-B2 1-phenyl imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders G.D. SEARLE & CO. (US) 2005-02-22 US disclosed
US-20050038035-A1 Heterocyclic amide compounds as apolipoprotein b inhibitors DAISO CO., LTD. (JP) 2005-02-17 US disclosed
US-20040133008-A1 Amide compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-07-08 US disclosed
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-03-25 US disclosed
US-20040048911-A1 1-phenyl imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders G. D. SEARLE & CO. 2004-03-11 US disclosed
US-6630497-B2 1-phenyl imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders G.D. SEARLE & CO 2003-10-07 US disclosed
US-20020038035-A1 1-phenyl imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders G.D. SEARLE & CO. 2002-03-28 US disclosed
EP-1160243-A1 PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVE OR SALT THEREOF FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-12-05 EP disclosed
US-4462999-A CEPHALOSPORINS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1984-07-31 US disclosed
EP-0108977-A2 Starting compounds for preparing 7-acylamino-3-substituted cephalosporanic acid derivatives and process for their preparation FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1984-05-23 EP disclosed
EP-0010667-B1 CEPHAM COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION THEREOF AND OF KNOWN CEPHEM COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1983-07-20 EP disclosed
EP-0073451-A2 Carbapenam compound and processes for the preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1983-03-09 EP disclosed
EP-0071891-A2 New cephem compounds and processes for preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1983-02-16 EP disclosed
US-4363807-A BACTERICIDES AND USEFUL ANTIBIOTIC INTERMEDIATES FUJISAWA PHARMACEUTICAL COMPANY, LIMITED (JP) 1982-12-14 US disclosed
EP-0029557-A2 7-Acylamino-3-substituted cephalosporanic acid derivatives, processes for their preparation and pharmaceutical compositions containing them FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1981-06-03 EP disclosed
EP-0010667-A1 Cepham compounds, pharmaceutical compositions containing them and processes for the preparation thereof and of known cephem compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1980-05-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020038035-A1 1-phenyl imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders AGTR1, AGTR2, REN AGTR1 1/4885AGTR2 2/4885
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors APOB, APOL1, SCARB1 AGTR1 227/4885AGTR2 264/4885
US-20040133008-A1 Amide compounds APOB, APOL1, LDLR AGTR1 10/4885AGTR2 17/4885
US-20040048911-A1 1-phenyl imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders AGTR1, AGTR2, REN AGTR1 1/4885AGTR2 2/4885
US-20050038035-A1 Heterocyclic amide compounds as apolipoprotein b inhibitors APOB, APOL1, CTRB2 AGTR1 11/4885AGTR2 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.