Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 4/20 | 0.47 |
| ▸ | ACHE | P22303 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504735 | 1.00 | MAPT (0.65) | MAPTL3MBTL1SMN1; SMN2ALDH1A1NPC1 | |
| Water SCHEMBL9210675 | 0.84 | L3MBTL1 (0.67) | MAPTL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL24627827 | 0.84 | L3MBTL1 (0.70) | MAPTL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5906811 | 0.84 | ALDH1A1 (0.68) | MAPTSMN1; SMN2ALDH1A1NPC1POLB | |
| SCHEMBL5906815 | 0.84 | ALDH1A1 (0.68) | MAPTSMN1; SMN2ALDH1A1NPC1POLB | |
| SCHEMBL9205258 | 0.83 | L3MBTL1 (0.75) | MAPTL3MBTL1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL20500014 | 0.82 | L3MBTL1 (0.74) | MAPTL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3811564 | 0.81 | L3MBTL1 (0.80) | MAPTL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6331080 | 0.80 | L3MBTL1 (0.71) | MAPTL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL20008740 | 0.80 | L3MBTL1 (0.71) | MAPTL3MBTL1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6864268-B2 | β3 adrenergic receptor agonists | PFIZER INC. (US) | 2005-03-08 | — | — | US | disclosed |
| EP-1485379-A1 | BETA 3-ADRENERGIC RECEPTOR AGONISTS | Pfizer Products Inc. (US) | 2004-12-15 | — | — | EP | disclosed |
| US-20030212063-A1 | beta3 adrenergic receptor agonists | PFIZER INC. | 2003-11-13 | — | — | US | disclosed |
| WO-2003072572-A1 | BETA3-ADRENERGIC RECEPTOR AGONISTS | PFIZER PRODUCTS INC. (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212063-A1 | beta3 adrenergic receptor agonists | ADRB3, ADRB1, ADRB2 | MAPT 1615/4885L3MBTL1 2895/4885SMN1; SMN2 1782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.