Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | TPMT | P51580 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496085 | 0.84 | KDM4E (0.63) | RAB9ASMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL3417072 | 0.80 | KDM4E (0.61) | RAB9ASMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL6495754 | 0.80 | MDM2 (0.47) | RAB9ASMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL3995172 | 0.78 | RARA (0.60) | SMN1; SMN2KDM4ENPC1KMT2AMEN1 | |
| SCHEMBL8867854 | 0.77 | RAB9A (0.72) | RAB9ASMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL6503762 | 0.76 | SHMT1 (0.56) | RAB9ASMN1; SMN2KDM4ENPC1MAPT | |
| SCHEMBL6496395 | 0.75 | PIN1 (0.54) | SMN1; SMN2KDM4EKMT2AMEN1MAPT | |
| SCHEMBL18004048 | 0.75 | KDM4E (0.41) | RAB9ASMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL6503223 | 0.74 | RARA (0.49) | RAB9ASMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL6498884 | 0.73 | DAO (0.44) | RAB9ASMN1; SMN2KDM4EPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |