Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RPA1 | P27694 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 2/20 | 0.41 |
| ▸ | RARB | P10826 | 2/20 | 0.41 |
| ▸ | RARG | P13631 | 2/20 | 0.41 |
| ▸ | EIF4E | P06730 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18003622 | 0.86 | KDM4E (0.47) | KDM4ENPC1RAB9ASMN1; SMN2ABL1 | |
| SCHEMBL6502591 | 0.83 | L3MBTL1 (0.47) | MDM2KMOKDM4ENPC1POLB | |
| SCHEMBL6496085 | 0.83 | KDM4E (0.63) | KDM4ENPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL6503223 | 0.80 | RARA (0.49) | KDM4ENPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL6504818 | 0.80 | RAB9A (0.44) | KMOKDM4ENPC1POLBRAB9A | |
| SCHEMBL16399348 | 0.77 | APEX1 (0.43) | KMOABL1TP53MAPTAPEX1 | |
| SCHEMBL16399903 | 0.77 | HTR2B (0.45) | KMOKDM4ENPC1POLBRAB9A | |
| SCHEMBL3417072 | 0.76 | KDM4E (0.61) | KDM4ENPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL4905599 | 0.75 | PTPN11 (0.43) | KDM4ENPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL6503762 | 0.75 | SHMT1 (0.56) | KDM4ENPC1RAB9ASMN1; SMN2EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |