Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.30 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.30 |
| ▸ | GPR3 | P46089 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 3/20 | 0.30 |
| ▸ | DRD4 | P21917 | 3/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28225814 | 0.79 | GPR3 (0.39) | GPR3CYP19A1HTR2AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL8416190 | 0.75 | TP53 (0.37) | CYP19A1HTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL8581359 | 0.75 | GPR3 (0.31) | GPR3 | |
| SCHEMBL358532 | 0.75 | GPR3 (0.39) | GPR3HTR2AHTR7HTR2BACHE | |
| SCHEMBL31338566 | 0.75 | GPR3 (0.39) | GPR3HTR2AHTR7HTR2BACHE | |
| Hydrochloric Acid SCHEMBL6443849 | 0.75 | — | — | |
| SCHEMBL29285278 | 0.73 | ALDH1A1 (0.41) | GPR3HTR2AHTR7HTR2BPOLB | |
| SCHEMBL12429503 | 0.73 | GPR3 (0.38) | GPR3HTR2AHTR7HTR2BHTR1A | |
| SCHEMBL30987013 | 0.73 | ALDH1A1 (0.41) | GPR3HTR2AHTR7HTR2BPOLB | |
| SCHEMBL28807674 | 0.73 | GPR3 (0.38) | GPR3CYP19A1HTR2AHTR7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8120084-B2 | Ferro-electric device and modulatable injection barrier | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2012-02-21 | — | — | US | claimed |
| JP-2010528471-A | — | — | 2010-08-19 | — | — | JP | claimed |
| US-20100171103-A1 | Ferro-Electric Device And Modulatable Injection Barrier | RIJIKSUNIVERSITEIT GRONINGEN (NL) | 2010-07-08 | — | — | US | claimed |
| EP-2158591-A1 | FERRO-ELECTRIC DEVICE AND MODULATABLE INJECTION BARRIER | Rijksuniversiteit Groningen (NL) | 2010-03-03 | — | — | EP | claimed |
| WO-2008143509-A1 | FERRO-ELECTRIC DEVICE AND MODULATABLE INJECTION BARRIER | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2008-11-27 | — | — | WO | claimed |
| EP-1995736-A1 | Ferro-electric device and modulatable injection barrier | Rijksuniversiteit Groningen (NL) | 2008-11-26 | — | — | EP | claimed |
| EP-0705851-B9 | Catalyst systems and process for producing broad molecular weight distribution polyolefin | CONOCOPHILLIPS CO (US) | 2004-08-11 | — | — | EP | claimed |
| EP-0705851-B1 | Catalyst systems and process for producing broad molecular weight distribution polyolefin | CONOCOPHILLIPS CO (US) | 2004-01-21 | — | — | EP | claimed |
| US-5594078-A | BRIDGED FLUORENYL METALLOCENE CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1997-01-14 | — | — | US | claimed |
| US-5534473-A | METALLOCENES AND COCATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1996-07-09 | — | — | US | claimed |
| EP-0705851-A2 | Catalyst systems and process for producing broad molecular weight distribution polyolefin | PHILLIPS PETROLEUM COMPANY (US) | 1996-04-10 | — | — | EP | claimed |
| WO-2019195170-A1 | BENZOXAZINE BLENDS | WESTERN WASHINGTON UNIVERSITY (US) | 2019-10-10 | — | — | WO | disclosed |
| EP-1852408-B1 | PROCESS FOR THE DIMERIZATION OF ALPHA-OLEFINS | IDEMITSU KOSAN CO (JP) | 2018-04-04 | — | — | EP | disclosed |
| US-9559320-B2 | Ferro-electric device and modulatable injection barrier | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 2017-01-31 | — | — | US | disclosed |
| US-20130225892-A1 | PROCESS FOR PRODUCING UNSATURATED HYDROCARBON COMPOUND | IDEMITSU KOSAN CO., LTD. (JP) | 2013-08-29 | — | — | US | disclosed |
| US-20090030255-A1 | PROCESS FOR PRODUCING UNSATURATED HYDROCARBON COMPOUND | IDEMITSU KOSAN CO., LTD. (JP) | 2009-01-29 | — | — | US | disclosed |
| WO-2008143509-A1 | FERRO-ELECTRIC DEVICE AND MODULATABLE INJECTION BARRIER | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2008-11-27 | — | — | WO | disclosed |
| EP-1995736-A1 | Ferro-electric device and modulatable injection barrier | Rijksuniversiteit Groningen (NL) | 2008-11-26 | — | — | EP | disclosed |
| EP-1852408-A1 | PROCESS FOR PRODUCING UNSATURATED HYDROCARBON COMPOUND | IDEMITSU KOSAN CO., LTD. (JP) | 2007-11-07 | — | — | EP | disclosed |
| EP-1849757-A1 | METHOD FOR PRODUCING UNSATURATED HYDROCARBON COMPOUND | IDEMITSU KOSAN CO., LTD. (JP) | 2007-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030255-A1 | PROCESS FOR PRODUCING UNSATURATED HYDROCARBON COMPOUND | ALOX12, ALOX15B, ALOX15 | CHRM2 2661/4885CHRM1 2038/4885ACHE 3810/4885 |
| US-20130225892-A1 | PROCESS FOR PRODUCING UNSATURATED HYDROCARBON COMPOUND | ALOX12, ALOX15B, ALOX15 | CHRM2 2661/4885CHRM1 2038/4885ACHE 3810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.