Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506448 | 0.84 | MAP2K1 (0.40) | MAP2K2MAP2K1ALDH1A1 | |
| SCHEMBL21069263 | 0.83 | HSD17B10 (0.48) | KDM4EHSD17B10ALOX15MEN1KMT2A | |
| SCHEMBL6467613 | 0.82 | ITK (0.49) | KDM4EMAP2K2MAP2K1ITK | |
| SCHEMBL6467593 | 0.76 | NPC1 (0.41) | KDM4EALDH1A1HSD17B10ALOX15ADORA2A | |
| SCHEMBL13557943 | 0.75 | MAP2K1 (0.42) | MAP2K2MAP2K1 | |
| SCHEMBL21070453 | 0.74 | GABRP (0.33) | KDM4EALDH1A1ADORA2AADORA1LMNA | |
| SCHEMBL6470420 | 0.73 | KDM4E (0.36) | KDM4EALDH1A1HSD17B10ALOX15ADORA2A | |
| SCHEMBL20022423 | 0.72 | HDAC9 (0.41) | KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL6499831 | 0.71 | SMN1; SMN2 (0.38) | KDM4EMAP2K2MAP2K1ALDH1A1LMNA | |
| SCHEMBL10258699 | 0.69 | GABRA2 (0.30) | GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | KDM4E 2424/4885MAP2K2 4197/4885MAP2K1 4663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.