Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 6/20 | 0.54 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.50 |
| ▸ | WNT3A | P56704 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18122013 | 0.85 | HSD17B1 (0.58) | HSD17B1HSD17B2CYP3A4CYP2C9KDR | |
| SCHEMBL18122016 | 0.83 | HSD17B1 (0.57) | HSD17B1HSD17B2CYP3A4CYP2C9KDR | |
| SCHEMBL11992043 | 0.79 | UHRF1 (0.58) | MAPK14WNT3AUHRF1PSEN1PSEN2 | |
| SCHEMBL19198689 | 0.77 | HSD17B1 (0.47) | HSD17B1HSD17B2CYP3A4CYP2C9KDR | |
| SCHEMBL2095263 | 0.75 | MEN1 (0.53) | HSD17B1HSD17B2CYP3A4CYP2C9MEN1 | |
| SCHEMBL10054038 | 0.75 | DYRK1A (0.43) | MAPK14WNT3AUHRF1 | |
| SCHEMBL3459364 | 0.75 | HSD17B1 (0.54) | HSD17B1HSD17B2CYP3A4CYP2C9KDR | |
| SCHEMBL2095261 | 0.73 | MEN1 (0.51) | HSD17B1HSD17B2CYP3A4CYP2C9MEN1 | |
| SCHEMBL10022358 | 0.73 | TLR8 (0.41) | WNT3AUHRF1 | |
| SCHEMBL9954813 | 0.72 | ALDH1A1 (0.54) | HSD17B1HSD17B2CYP3A4CYP2C9MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050080113-A1 | Medicinal compositions | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080113-A1 | Medicinal compositions | TNF, TRAF6, MMP8 | HSD17B1 3394/4885HSD17B2 3560/4885CYP3A4 4806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.