Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 5/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5173018 | 1.00 | OPRL1 (0.47) | OPRL1METAP2KMT2AMEN1TSHR | |
| SCHEMBL2700026 | 0.81 | CYP1A2 (0.39) | KMT2AMEN1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL617771 | 0.80 | KMT2A (0.33) | KMT2A | |
| SCHEMBL23247913 | 0.80 | ALDH1A1 (0.37) | KMT2AMEN1SMN1; SMN2OPRM1ALDH1A1 | |
| SCHEMBL1273336 | 0.78 | HPGD (0.46) | OPRL1METAP2KMT2AMEN1TSHR | |
| SCHEMBL17007539 | 0.76 | SMN1; SMN2 (0.43) | KMT2AMEN1TSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL1982112 | 0.75 | NPSR1 (0.39) | KMT2AMEN1TSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL14968931 | 0.74 | TSHR (0.46) | OPRL1METAP2KMT2AMEN1TSHR | |
| SCHEMBL17801011 | 0.74 | DGAT1 (0.33) | — | |
| SCHEMBL1273271 | 0.74 | MMP1 (0.42) | OPRL1KMT2AMEN1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CHENG HENGMIAO | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CYP11B1, HSD11B1, CYP11B2 | OPRL1 590/4885METAP2 412/4885KMT2A 3470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.