Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376894 | 0.87 | CA12 (0.39) | TDP1 | |
| SCHEMBL1260015 | 0.85 | TSHR (0.34) | TDP1 | |
| SCHEMBL1260004 | 0.79 | TSHR (0.31) | — | |
| SCHEMBL6400032 | 0.77 | TDP1 (0.39) | TDP1 | |
| SCHEMBL8847261 | 0.76 | CA12 (0.36) | TDP1 | |
| SCHEMBL20274393 | 0.75 | ALDH1A1 (0.37) | — | |
| SCHEMBL7632460 | 0.75 | TET2 (0.34) | — | |
| SCHEMBL8373314 | 0.74 | CA12 (0.38) | TDP1 | |
| SCHEMBL28325486 | 0.74 | CA12 (0.40) | — | |
| SCHEMBL27829714 | 0.73 | TDP1 (0.33) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107543-A1 | Fluoro linkers and their use as linkers for enzyme-activated drug conjugates | PFIZER INC. | 2005-05-19 | — | — | US | claimed |
| EP-1414792-A1 | FLUORO LINKERS AND THEIR USE AS LINKERS FOR ENZYME-ACTIVATED DRUG CONJUGATES | Pharmacia Italia S.p.A. (IT) | 2004-05-06 | — | — | EP | claimed |
| EP-1019090-B1 | POLYMERIC DERIVATIVES OF CAMPTOTHECINS | PHARMACIA ITALIA SPA (IT) | 2004-02-18 | — | — | EP | claimed |
| US-20030195152-A1 | Polymeric conjugates of antitumor agents | PHARMACIA ITALIA, S.P.A. (IT) | 2003-10-16 | — | — | US | claimed |
| EP-1317287-A2 | POLYMERIC CONJUGATES OF ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2003-06-11 | — | — | EP | claimed |
| EP-0673258-B1 | POLYMER-BOUND CAMPTOTHECIN DERIVATIVES | PHARMACIA ITALIA SPA (IT) | 2003-05-07 | — | — | EP | claimed |
| WO-2003014069-A1 | FLUORO LINKERS AND THEIR USE AS LINKERS FOR ENZYME-ACTIVATED DRUG CONJUGATES | PHARMACIA ITALIA SPA (IT) | 2003-02-20 | — | — | WO | claimed |
| US-6376617-B1 | ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-04-23 | — | — | US | claimed |
| US-20020032331-A1 | BIOACTIVE DERIVATIVES OF CAMPTOTHECIN | PHARMACIA ITALIA S.P.A. (IT) | 2002-03-14 | — | — | US | claimed |
| WO-2002007770-A2 | POLYMERIC CONJUGATES OF ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2002-01-31 | — | — | WO | claimed |
| US-6328953-B1 | AS ANTITUMOR AGENT AND REDUCED TOXICITY | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-12-11 | — | — | US | claimed |
| WO-2001000240-A2 | ANTITUMOR COMPOUND | PHARMACIA & UPJOHN SPA (IT) | 2001-01-04 | — | — | WO | claimed |
| EP-1019090-A1 | POLYMERIC DERIVATIVES OF CAMPTOTHECINS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | claimed |
| EP-0944400-A1 | BIOACTIVE DERIVATIVES OF CAMPTOTHECIN | PHARMACIA & UPJOHN S.p.A. (IT) | 1999-09-29 | — | — | EP | claimed |
| WO-1999017804-A1 | POLYMERIC DERIVATIVES OF CAMPTOTHECINS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-15 | — | — | WO | claimed |
| WO-1999017805-A1 | BIOACTIVE DERIVATIVES OF CAMPTOTHECIN | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-15 | — | — | WO | claimed |
| US-5773522-A | PRODRUGS FOR TREATMENT OF TUMORS | PHARMACIA S.P.A. (IT) | 1998-06-30 | — | — | US | claimed |
| EP-0673258-A1 | POLYMER-BOUND CAMPTOTHECIN DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-09-27 | — | — | EP | claimed |
| WO-1995010304-A1 | POLYMER-BOUND CAMPTOTHECIN DERIVATIVES | PHARMACIA S.P.A (IT) | 1995-04-20 | — | — | WO | claimed |
| US-20050107543-A1 | Fluoro linkers and their use as linkers for enzyme-activated drug conjugates | PFIZER INC. | 2005-05-19 | — | — | US | disclosed |
| EP-1414792-A1 | FLUORO LINKERS AND THEIR USE AS LINKERS FOR ENZYME-ACTIVATED DRUG CONJUGATES | Pharmacia Italia S.p.A. (IT) | 2004-05-06 | — | — | EP | disclosed |
| EP-1019090-B1 | POLYMERIC DERIVATIVES OF CAMPTOTHECINS | PHARMACIA ITALIA SPA (IT) | 2004-02-18 | — | — | EP | disclosed |
| CN-1138565-C | Polymer-bound camptothecin derivatives | ������˹ҩƷ��˾ | 2004-02-18 | — | — | CN | disclosed |
| US-20030195152-A1 | Polymeric conjugates of antitumor agents | PHARMACIA ITALIA, S.P.A. (IT) | 2003-10-16 | — | — | US | disclosed |
| EP-1317287-A2 | POLYMERIC CONJUGATES OF ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2003-06-11 | — | — | EP | disclosed |
| EP-0673258-B1 | POLYMER-BOUND CAMPTOTHECIN DERIVATIVES | PHARMACIA ITALIA SPA (IT) | 2003-05-07 | — | — | EP | disclosed |
| EP-0673258-B1 | POLYMER-BOUND CAMPTOTHECIN DERIVATIVES | PHARMACIA ITALIA SPA (IT) | 2003-05-07 | — | — | EP | disclosed |
| WO-2003014069-A1 | FLUORO LINKERS AND THEIR USE AS LINKERS FOR ENZYME-ACTIVATED DRUG CONJUGATES | PHARMACIA ITALIA SPA (IT) | 2003-02-20 | — | — | WO | disclosed |
| US-6376617-B1 | ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-04-23 | — | — | US | disclosed |
| US-20020032331-A1 | BIOACTIVE DERIVATIVES OF CAMPTOTHECIN | PHARMACIA ITALIA S.P.A. (IT) | 2002-03-14 | — | — | US | disclosed |
| WO-2002007770-A2 | POLYMERIC CONJUGATES OF ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |
| US-6328953-B1 | AS ANTITUMOR AGENT AND REDUCED TOXICITY | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |
| WO-2001000240-A2 | ANTITUMOR COMPOUND | PHARMACIA & UPJOHN SPA (IT) | 2001-01-04 | — | — | WO | disclosed |
| EP-1019090-A1 | POLYMERIC DERIVATIVES OF CAMPTOTHECINS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| EP-0944400-A1 | BIOACTIVE DERIVATIVES OF CAMPTOTHECIN | PHARMACIA & UPJOHN S.p.A. (IT) | 1999-09-29 | — | — | EP | disclosed |
| WO-1999017804-A1 | POLYMERIC DERIVATIVES OF CAMPTOTHECINS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-15 | — | — | WO | disclosed |
| WO-1999017805-A1 | BIOACTIVE DERIVATIVES OF CAMPTOTHECIN | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-15 | — | — | WO | disclosed |
| US-5773522-A | PRODRUGS FOR TREATMENT OF TUMORS | PHARMACIA S.P.A. (IT) | 1998-06-30 | — | — | US | disclosed |
| US-5773522-A | PRODRUGS FOR TREATMENT OF TUMORS | PHARMACIA S.P.A. (IT) | 1998-06-30 | — | — | US | disclosed |
| CN-1115564-A | Polymer-bound camptothecin derivatives | PHARMACIA SPA (IT) | 1996-01-24 | — | — | CN | disclosed |
| EP-0673258-A1 | POLYMER-BOUND CAMPTOTHECIN DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-09-27 | — | — | EP | disclosed |
| EP-0673258-A1 | POLYMER-BOUND CAMPTOTHECIN DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-09-27 | — | — | EP | disclosed |
| WO-1995010304-A1 | POLYMER-BOUND CAMPTOTHECIN DERIVATIVES | PHARMACIA S.P.A (IT) | 1995-04-20 | — | — | WO | disclosed |
| WO-1995010304-A1 | POLYMER-BOUND CAMPTOTHECIN DERIVATIVES | PHARMACIA S.P.A (IT) | 1995-04-20 | — | — | WO | disclosed |
| WO-1995010304-A1 | POLYMER-BOUND CAMPTOTHECIN DERIVATIVES | PHARMACIA S.P.A (IT) | 1995-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195152-A1 | Polymeric conjugates of antitumor agents | MMP11, MMP3, MMP10 | TDP1 1913/4885 |
| US-20020032331-A1 | BIOACTIVE DERIVATIVES OF CAMPTOTHECIN | VIP, TOP2A, AMPD2 | TDP1 929/4885 |
| US-20050107543-A1 | Fluoro linkers and their use as linkers for enzyme-activated drug conjugates | CES2, CBR3, APEH | TDP1 1698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.