Sugi Predict

Sugi Predict / Compounds / Styrene

Styrene

Styrene

SCHEMBL6509931

C=C(CC=C(C)C(=O)O)C(=O)OC.C=CC(=O)OCCCC.C=Cc1ccccc1

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 4/20 0.44
▸ HPGD P15428 1/20 0.44
▸ KDM4E B2RXH2 2/20 0.39
▸ TDP1 Q9NUW8 3/20 0.37
▸ THRB P10828 3/20 0.37
▸ L3MBTL1 Q9Y468 2/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ THRA P10827 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ APP P05067 1/20 0.33
▸ ALDH1A1 P00352 2/20 0.33
▸ CYP3A4 P08684 2/20 0.33
▸ MEN1 O00255 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ NPC1 O15118 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ MAPK1 P28482 1/20 0.32
▸ HCAR2 Q8TDS4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Styrene SCHEMBL7903209 0.94 TSHR (0.46) TSHRHPGDKDM4ETDP1THRB
Styrene SCHEMBL16752625 0.91 TSHR (0.38) TSHRHPGDKDM4ETDP1THRB
Styrene SCHEMBL5733434 0.90 TSHR (0.42) TSHRHPGDKDM4ETDP1THRB
Styrene SCHEMBL9699304 0.90 MEN1 (0.39) HPGDKDM4ETDP1THRBL3MBTL1
SCHEMBL2878453 0.89 TSHR (0.55) TSHRHPGDTHRBALDH1A1CYP3A4
SCHEMBL5361438 0.89 TSHR (0.55) TSHRHPGDTHRBALDH1A1CYP3A4
Styrene SCHEMBL5444349 0.88 KDM4E (0.43) TSHRHPGDKDM4ETDP1L3MBTL1
SCHEMBL11413027 0.86 KDM4E (0.40) TSHRHPGDKDM4ETDP1THRB
Acrylic Acid Ethyl Ester SCHEMBL8102856 0.86 TSHR (0.51) TSHRHPGDTHRBALDH1A1CYP3A4
Styrene SCHEMBL3343449 0.86 AKR1C3 (0.41) TSHRSMN1; SMN2ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050226831-A1 Iridescent cosmetic composition and use thereof L'OREAL (FR) 2005-10-13 — — US claimed
US-6946124-B2 Iridescent cosmetic composition and use thereof L'OREAL (FR) 2005-09-20 — — US claimed
US-20030053979-A1 Iridescent cosmetic composition and uses thereof L'OREAL (FR) 2003-03-20 — — US claimed
US-20030021817-A1 Iridescent cosmetic composition and uses thereof L'OREAL (FR) 2003-01-30 — — US claimed
US-20030012802-A1 Iridescent cosmetic composition and use thereof L'OREAL (FR) 2003-01-16 — — US claimed
US-20050226831-A1 Iridescent cosmetic composition and use thereof L'OREAL (FR) 2005-10-13 — — US disclosed
US-6946124-B2 Iridescent cosmetic composition and use thereof L'OREAL (FR) 2005-09-20 — — US disclosed
US-20030053979-A1 Iridescent cosmetic composition and uses thereof L'OREAL (FR) 2003-03-20 — — US disclosed
US-20030021817-A1 Iridescent cosmetic composition and uses thereof L'OREAL (FR) 2003-01-30 — — US disclosed
US-20030012802-A1 Iridescent cosmetic composition and use thereof L'OREAL (FR) 2003-01-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030021817-A1 Iridescent cosmetic composition and uses thereof INCENP, LAGE3, CUTA TSHR 4510/4885HPGD 1444/4885KDM4E 2824/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.