Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6518559 | 0.83 | SMN1; SMN2 (0.55) | ALDH1A1SMN1; SMN2LMNAHPGDMAPT | |
| SCHEMBL27341477 | 0.78 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2LMNAMAPTNPC1 | |
| SCHEMBL5923393 | 0.78 | MAPT (0.50) | ALDH1A1SMN1; SMN2LMNAHPGDMAPT | |
| SCHEMBL6507333 | 0.77 | BCHE (0.44) | SMN1; SMN2LMNAMAPTKMT2AMEN1 | |
| SCHEMBL6518218 | 0.77 | RECQL (0.51) | ALDH1A1SMN1; SMN2LMNAHPGDMAPT | |
| SCHEMBL6511110 | 0.76 | SIGMAR1 (0.41) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL6511310 | 0.75 | KMT2A (0.54) | ALDH1A1SMN1; SMN2LMNAHPGDMAPT | |
| SCHEMBL6510506 | 0.73 | MAPK1 (0.56) | ALDH1A1SMN1; SMN2LMNAHPGDMAPT | |
| SCHEMBL6507347 | 0.72 | LMNA (0.52) | ALDH1A1SMN1; SMN2LMNAHPGDMAPT | |
| SCHEMBL10501444 | 0.72 | CYP1A2 (0.49) | ALDH1A1SMN1; SMN2LMNANPC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |