Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6518559 | 0.83 | SMN1; SMN2 (0.55) | RECQLNPC1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6509978 | 0.82 | NOS3 (0.48) | NPC1CYP1A2MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL6509226 | 0.78 | NOS3 (0.46) | SMN1; SMN2LMNAALDH1A1HPGDNOS3 | |
| SCHEMBL5923046 | 0.77 | NPY5R (0.55) | RECQLNPC1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6510702 | 0.77 | ALDH1A1 (0.48) | RECQLNPC1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6510782 | 0.76 | NOS3 (0.45) | NPC1SMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL6513366 | 0.76 | ALDH1A1 (0.53) | MAPK1LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL6511310 | 0.76 | KMT2A (0.54) | RECQLNPC1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6155618 | 0.74 | SIGMAR1 (0.54) | LMNAKMT2ANOS3NOS1NOS2 | |
| SCHEMBL6507347 | 0.73 | LMNA (0.52) | RECQLNPC1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |