Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.46 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.46 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510224 | 0.87 | RAB9A (0.50) | MAPK1RAB9ACYP2D6CYP3A4CYP2C9 | |
| SCHEMBL6510696 | 0.85 | RAB9A (0.59) | MAPK1RAB9ACYP2D6CYP3A4CYP2C9 | |
| SCHEMBL6507381 | 0.81 | RAB9A (0.54) | MAPK1RAB9AMEN1KMT2APHGDH | |
| SCHEMBL5923622 | 0.75 | MEN1 (0.43) | MAPK1RAB9ACYP2D6CYP3A4CYP2C9 | |
| SCHEMBL5923669 | 0.70 | MAPK1 (0.43) | MAPK1RAB9AMEN1KMT2APHGDH | |
| SCHEMBL15938854 | 0.68 | RAC1 (0.67) | SIGMAR1PHGDHALDH1A1LMNAGRIN2D | |
| SCHEMBL5923410 | 0.68 | MAPK1 (0.48) | MAPK1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL6511078 | 0.67 | GRIN2D (0.43) | MAPK1CYP2D6CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL6515320 | 0.66 | SIGMAR1 (0.46) | MAPK1RAB9ACYP2D6CYP1A2SIGMAR1 | |
| SCHEMBL6510332 | 0.65 | KMT2A (0.55) | RAB9ASIGMAR1MEN1KMT2APHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |