Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 8/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6515324 | 0.89 | MAPT (0.41) | MAPK1L3MBTL1DHFRCYP2D6TSHR | |
| SCHEMBL6518505 | 0.84 | C5AR1 (0.37) | L3MBTL1LTB4R | |
| SCHEMBL6516516 | 0.83 | ALDH1A1 (0.41) | POLBCYP2D6 | |
| SCHEMBL6522088 | 0.80 | NPSR1 (0.36) | MAPK1L3MBTL1POLB | |
| SCHEMBL1328160 | 0.80 | C5AR1 (0.41) | L3MBTL1TSHR | |
| SCHEMBL1326819 | 0.79 | MAPK1 (0.36) | MAPK1L3MBTL1DHFRCYP2D6TSHR | |
| SCHEMBL6523352 | 0.75 | C5AR1 (0.38) | L3MBTL1CNR1CNR2 | |
| SCHEMBL6522038 | 0.72 | C5AR1 (0.33) | L3MBTL1 | |
| SCHEMBL6514263 | 0.72 | C5AR1 (0.44) | CYP2D6 | |
| SCHEMBL6522043 | 0.71 | PPARA (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565452-A2 | 3-SUBSTITUTED-6-ARYL PYRIDINES AS LIGANDS OF C5A RECEPTORS | NEUROGEN CORPORATION (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004043925-A2 | 3-SUBSTITUTED-6-ARYL PYRIDINED AS LIGANDS OF C5A RECEPTORS | NEUROGEN CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |