Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | DHFR | P00374 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6515014 | 0.89 | MAPK1 (0.40) | TSHRMAPK1CYP2D6L3MBTL1DHFR | |
| SCHEMBL6516516 | 0.87 | ALDH1A1 (0.41) | ALDH1A1CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL6522088 | 0.85 | NPSR1 (0.36) | MAPTLMNAKDM4EALDH1A1NPSR1 | |
| SCHEMBL6518505 | 0.84 | C5AR1 (0.37) | MAPTALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL6523352 | 0.80 | C5AR1 (0.38) | L3MBTL1 | |
| SCHEMBL1329562 | 0.79 | MEN1 (0.40) | MAPTLMNAALDH1A1MAPK1CYP1A2 | |
| SCHEMBL1328624 | 0.78 | ACACB (0.38) | MAPTLMNAKDM4EALDH1A1NPSR1 | |
| SCHEMBL1328160 | 0.77 | C5AR1 (0.41) | MAPTALDH1A1NPSR1TSHRL3MBTL1 | |
| SCHEMBL6522038 | 0.77 | C5AR1 (0.33) | MAPTNPSR1L3MBTL1 | |
| SCHEMBL1327067 | 0.77 | RXRA (0.35) | MAPTLMNAKDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565452-A2 | 3-SUBSTITUTED-6-ARYL PYRIDINES AS LIGANDS OF C5A RECEPTORS | NEUROGEN CORPORATION (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004043925-A2 | 3-SUBSTITUTED-6-ARYL PYRIDINED AS LIGANDS OF C5A RECEPTORS | NEUROGEN CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |