Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21587530 | 0.84 | PTGS1 (0.54) | PTGS1LMNAHTTALDH1A1ATM | |
| SCHEMBL3669626 | 0.80 | LTB4R (0.43) | ALDH1A1TDP2MEN1KMT2AHPGD | |
| SCHEMBL13760654 | 0.79 | MAPT (0.44) | LMNAHTTALDH1A1ATML3MBTL1 | |
| SCHEMBL12790854 | 0.78 | ALDH1A1 (0.55) | PTGS1LMNAHTTALDH1A1ATM | |
| SCHEMBL3662731 | 0.77 | HSD17B10 (0.50) | PTGS1LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL6517154 | 0.76 | L3MBTL1 (0.57) | PTGS1LMNAHTTALDH1A1ATM | |
| SCHEMBL3667325 | 0.74 | HDAC6 (0.49) | LMNAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL11496756 | 0.73 | GRM6 (0.54) | PTGS1LMNAHTTALDH1A1ATM | |
| SCHEMBL10460681 | 0.72 | PTGS1 (0.50) | PTGS1LMNAHTTALDH1A1ATM | |
| SCHEMBL16502243 | 0.71 | PTGS1 (0.73) | PTGS1LMNAHTTALDH1A1GRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110059118-A1 | INHIBITORS OF JAK | DE VICENTE FIDALGO JAVIER | 2011-03-10 | — | — | US | claimed |
| US-8618103-B2 | Inhibitors of JAK | HOFFMANN-LA ROCHE INC. (US) | 2013-12-31 | — | — | US | disclosed |
| US-20110059118-A1 | INHIBITORS OF JAK | DE VICENTE FIDALGO JAVIER | 2011-03-10 | — | — | US | disclosed |
| US-20110054017-A1 | SUBSTITUTED FURANS AND THEIR USE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2011-03-03 | — | — | US | disclosed |
| US-20110054017-A1 | SUBSTITUTED FURANS AND THEIR USE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2011-03-03 | — | — | US | disclosed |
| US-20110054017-A1 | SUBSTITUTED FURANS AND THEIR USE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2011-03-03 | — | — | US | disclosed |
| WO-2009097991-A1 | SUBSTITUTED FURANS AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059118-A1 | INHIBITORS OF JAK | JAK1, JAK3, JAK2 | PTGS1 692/4885LMNA 4015/4885HTT 4201/4885 |
| US-20110054017-A1 | SUBSTITUTED FURANS AND THEIR USE | XDH, TXN2, FABP3 | PTGS1 50/4885LMNA 443/4885HTT 2233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.