Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29445159 | 1.00 | TDP1 (0.58) | TDP1ATMALDH1A1MAPK1RAB9A | |
| Ammonia Solution, Strong SCHEMBL20536780 | 0.98 | TDP1 (0.56) | TDP1ATMALDH1A1MAPK1RAB9A | |
| SCHEMBL5857081 | 0.90 | TDP1 (0.51) | TDP1ATMALDH1A1MAPK1RAB9A | |
| SCHEMBL30936866 | 0.88 | ATM (0.53) | TDP1ATMALDH1A1MAPK1RAB9A | |
| SCHEMBL3192746 | 0.85 | ALDH1A1 (0.56) | ALDH1A1MAPK1RAB9AMEN1KMT2A | |
| SCHEMBL29744326 | 0.85 | ALDH1A1 (0.56) | ALDH1A1MAPK1RAB9AMEN1KMT2A | |
| SCHEMBL17786752 | 0.85 | ATM (0.62) | TDP1ATMALDH1A1MEN1KMT2A | |
| SCHEMBL572373 | 0.83 | PTGES (0.55) | TDP1ATMMAPK1RAB9AMEN1 | |
| SCHEMBL1662886 | 0.82 | ALDH1A1 (0.65) | ALDH1A1MAPK1RAB9AMEN1KMT2A | |
| SCHEMBL14015561 | 0.82 | RAB9A (0.44) | TDP1ATMALDH1A1MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 494 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115521309-A | Iruaoke impurity and preparation method thereof | 思科(深圳)药物研发有限公司 | 2022-12-27 | — | — | CN | claimed |
| CN-112480083-A | AZD9291 derivative containing alkynyl and preparation method and application thereof | 上海应用技术大学 | 2021-03-12 | — | — | CN | claimed |
| CN-106220516-B | A kind of synthetic method of the fluoro- 4-aminophenol of 3- | 施海峰 | 2018-06-15 | — | — | CN | claimed |
| CN-106220516-A | A kind of synthetic method of 3 fluorine 4 amino-phenols | 叶芳 | 2016-12-14 | — | — | CN | claimed |
| US-20260048035-A1 | MODULATORS OF TNF-ALPHA ACTIVITY | FORWARD THERAPEUTICS INC (US) | 2026-02-19 | — | — | US | disclosed |
| US-12521368-B2 | Modulators of TNF-alpha activity | FORWARD THERAPEUTICS, INC. (US) | 2026-01-13 | — | — | US | disclosed |
| US-12473263-B2 | Bicyclic inhibitors of CBX chromodomains | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2025-11-18 | — | — | US | disclosed |
| US-20250345310-A1 | MODULATORS OF TNF-ALPHA ACTIVITY | FORWARD THERAPEUTICS INC (US) | 2025-11-13 | — | — | US | disclosed |
| US-12365695-B2 | Fused ring heteroaryl compounds as RIPK1 inhibitors | BISICHEM CO., LTD. (KR) | 2025-07-22 | — | — | US | disclosed |
| WO-2025137267-A1 | MODULATORS OF TNF-ALPHA ACTIVITY | FORWARD THERAPEUTICS, INC. (US) | 2025-06-26 | — | — | WO | disclosed |
| US-20250161291-A1 | SMALL MOLECULES FOR INHIBITING CHEMOKINE ACTIVITY AND/OR CANCER CELLS GROWTH | ALONBIO LTD. (IL) | 2025-05-22 | — | — | US | disclosed |
| US-20250154104-A1 | SMALL MOLECULES FOR TREATING CANCER, INHIBITING CHEMOKINE ACTIVITY AND/OR INDUCING CELL DEATH | ALONBIO LTD. (IL) | 2025-05-15 | — | — | US | disclosed |
| US-5019588-A | Nonhabit-forming analgeiscs | WARNER-LAMBERT COMPANY (US) | 1991-05-28 | — | — | US | disclosed |
| EP-0380063-A1 | 1,2-cyclohexylaminoaryl amides useful as analgesic agents | WARNER-LAMBERT COMPANY (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4906655-A | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents | WARNER-LAMBERT COMPANY (US) | 1990-03-06 | — | — | US | disclosed |
| US-4182872-A | CORRESPONDING 4-CARBOBENZOXY COMPOUNDS, 2,3,4,4A-TETRAHYDRO-1H-PYRAZINO(1,2-A)QUINOXALIN-5(6H)-ONES, 2,3,4,4A,5,6-HEXAHYDRO-1H-PYRAZINO(1,2-A)QUINOXALINES, HYPOTENSIVE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-01-08 | — | — | US | disclosed |
| US-4182869-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-01-08 | — | — | US | disclosed |
| US-4138567-A | HYPOTENSIVE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1979-02-06 | — | — | US | disclosed |
| US-4089958-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1978-05-16 | — | — | US | disclosed |
| US-4032639-A | 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12473263-B2 | Bicyclic inhibitors of CBX chromodomains | CBX2, CBX3, CBX6 | TDP1 2682/4885ATM 4632/4885ALDH1A1 2952/4885 |
| US-12365695-B2 | Fused ring heteroaryl compounds as RIPK1 inhibitors | RIPK1, RIPK3, RIPK4 | TDP1 403/4885ATM 2219/4885ALDH1A1 4793/4885 |
| US-20250154104-A1 | SMALL MOLECULES FOR TREATING CANCER, INHIBITING CHEMOKINE ACTIVITY AND/OR INDUCING CELL DEATH | CCL2, CXCR2, CCL5 | TDP1 2623/4885ATM 2257/4885ALDH1A1 1330/4885 |
| US-20250161291-A1 | SMALL MOLECULES FOR INHIBITING CHEMOKINE ACTIVITY AND/OR CANCER CELLS GROWTH | CCL2, CXCR2, CCL5 | TDP1 2317/4885ATM 1079/4885ALDH1A1 2699/4885 |
| US-20260048035-A1 | MODULATORS OF TNF-ALPHA ACTIVITY | TNF, TNFRSF1A, CD40 | TDP1 501/4885ATM 3156/4885ALDH1A1 2214/4885 |
| US-20250345310-A1 | MODULATORS OF TNF-ALPHA ACTIVITY | TNF, TNFRSF1A, NFKBIA | TDP1 1565/4885ATM 3874/4885ALDH1A1 2810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.