Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6522978 | 0.86 | KEAP1 (0.43) | — | |
| SCHEMBL9321175 | 0.67 | MTNR1A (0.47) | EGFRSRCCAPN1NR4A2KDM4E | |
| SCHEMBL9632170 | 0.65 | MTNR1A (0.34) | EGFRSRCATMMTNR1A | |
| SCHEMBL6206188 | 0.65 | PTGER4 (0.58) | NR4A2 | |
| SCHEMBL3053811 | 0.64 | TAAR1 (0.55) | KDM4EMTNR1A | |
| SCHEMBL30341383 | 0.64 | TAAR1 (0.55) | KDM4EMTNR1A | |
| SCHEMBL20825056 | 0.62 | SIGMAR1 (0.45) | KDM4E | |
| SCHEMBL27918771 | 0.62 | MPO (0.50) | ATMMTNR1A | |
| SCHEMBL2593 | 0.62 | KEAP1 (0.67) | CAPN1PRMT1 | |
| Urea SCHEMBL6255302 | 0.61 | KMT2A (0.50) | SRCKDM4EBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0309626-B1 | PROCESS FOR THE PREPARATION OF DIBENZOTHIEPIN DERIVATIVE | NIPPON CHEMIPHAR CO., LTD. (JP) | 1992-05-06 | — | — | EP | disclosed |
| US-4891433-A | Process for the preparation of dibenzothiepin derivative | NIPPON CHEMIPHAR CO., LTD. (JP) | 1990-01-02 | — | — | US | disclosed |
| EP-0309626-A1 | Process for the preparation of dibenzothiepin derivative | NIPPON CHEMIPHAR CO., LTD. (JP) | 1989-04-05 | — | — | EP | disclosed |