Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11792843 | 0.88 | TDP1 (0.42) | L3MBTL1ALDH1A1LMNATDP1TRPV4 | |
| SCHEMBL6182053 | 0.85 | L3MBTL1 (0.61) | L3MBTL1SMN1; SMN2ALDH1A1LMNATDP1 | |
| SCHEMBL948440 | 0.84 | LMNA (0.49) | SMN1; SMN2ALDH1A1LMNATDP1G6PD | |
| SCHEMBL6749490 | 0.82 | SMN1; SMN2 (0.53) | L3MBTL1SMN1; SMN2ALDH1A1LMNAG6PD | |
| SCHEMBL14427193 | 0.81 | HTT (0.41) | L3MBTL1SMN1; SMN2ALDH1A1LMNATDP1 | |
| SCHEMBL6747614 | 0.80 | TRPV4 (0.50) | SMN1; SMN2ALDH1A1LMNAG6PDIDE | |
| SCHEMBL2228430 | 0.80 | L3MBTL1 (0.50) | L3MBTL1SMN1; SMN2ALDH1A1LMNATDP1 | |
| SCHEMBL14495147 | 0.80 | L3MBTL1 (0.46) | L3MBTL1SMN1; SMN2ALDH1A1LMNATDP1 | |
| SCHEMBL11348441 | 0.77 | TRPV4 (0.41) | L3MBTL1ALDH1A1TDP1TRPV4PTGS2 | |
| SCHEMBL692131 | 0.77 | ALDH1A1 (0.47) | L3MBTL1SMN1; SMN2ALDH1A1LMNATRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051655-B1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2005-09-28 | — | — | EP | disclosed |
| EP-1051655-A4 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2003-03-19 | — | — | EP | disclosed |
| US-20010016731-A1 | Methods and apparatus for accelerated orthokeratology | DEVORE DALE (US) | 2001-08-23 | — | — | US | disclosed |
| US-6161544-A | Methods for accelerated orthokeratology | KERATOFORM, INC. (US) | 2000-12-19 | — | — | US | disclosed |
| EP-1051655-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | Ista Pharmaceuticals, Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999039238-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | KERATOFORM, INC. (US) | 1999-08-05 | — | — | WO | disclosed |