Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Quazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALB | P02768 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | GHSR | Q92847 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Halazepam SCHEMBL7624840 | 0.84 | OPRK1 (0.68) | LMNAMEN1ALBKMT2AOPRK1 | |
| Quazepam SCHEMBL7614495 | 0.82 | LMNA (0.55) | LMNAOPRK1NR1I2ADORA3OPRM1 | |
| Quazepam SCHEMBL29504 | 0.82 | OPRK1 (0.58) | LMNAOPRK1NR1I2ADORA3OPRM1 | |
| Quazepam SCHEMBL29534458 | 0.82 | OPRK1 (0.58) | LMNAOPRK1NR1I2ADORA3OPRM1 | |
| Quazepam SCHEMBL1181404 | 0.82 | OPRK1 (0.66) | LMNAALBOPRK1NR1I2ADORA3 | |
| Halazepam SCHEMBL8319463 | 0.81 | OPRK1 (0.61) | LMNAMEN1ALBKMT2AOPRK1 | |
| Quazepam SCHEMBL21647120 | 0.81 | OPRK1 (0.57) | LMNAOPRK1NR1I2ADORA3OPRM1 | |
| Prazepam SCHEMBL7537961 | 0.77 | LMNA (0.64) | LMNAMEN1ALBKMT2AOPRK1 | |
| SCHEMBL7871697 | 0.77 | CYP3A4 (0.55) | LMNAOPRK1NR1I2ADORA3OPRM1 | |
| SCHEMBL5379874 | 0.77 | OPRK1 (0.77) | LMNAMEN1ALBKMT2AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414343-A4 | ELECTROENCEPAHLOGRAPHY BASED SYSTEMS AND METHODS FOR SELECTING THERAPIES AND PREDICTING OUTCOMES | CNS RESPONSE INC (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1414343-A2 | ELECTROENCEPAHLOGRAPHY BASED SYSTEMS AND METHODS FOR SELECTING THERAPIES AND PREDICTING OUTCOMES | CNS Response, Inc. (US) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003005899-A2 | ELECTROENCEPAHLOGRAPHY BASED SYSTEMS AND METHODS FOR SELECTING THERAPIES AND PREDICTING OUTCOMES | CNS RESPONSE, INC. (US) | 2003-01-23 | — | — | WO | disclosed |