Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Halazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 3/20 | 0.53 |
| ▸ | GABRA5 known ✓ | P31644 | 3/20 | 0.53 |
| ▸ | GABRA2 known ✓ | P47869 | 3/20 | 0.53 |
| ▸ | GABRB2 known ✓ | P47870 | 3/20 | 0.53 |
| ▸ | GABRP known ✓ | O00591 | 2/20 | 0.53 |
| ▸ | GABRD known ✓ | O14764 | 2/20 | 0.53 |
| ▸ | GABRB1 known ✓ | P18505 | 2/20 | 0.53 |
| ▸ | GABRG2 known ✓ | P18507 | 2/20 | 0.53 |
| ▸ | GABRB3 known ✓ | P28472 | 2/20 | 0.53 |
| ▸ | GABRA3 known ✓ | P34903 | 2/20 | 0.53 |
| ▸ | GABRA4 known ✓ | P48169 | 2/20 | 0.53 |
| ▸ | GABRE known ✓ | P78334 | 2/20 | 0.53 |
| ▸ | GABRA6 known ✓ | Q16445 | 2/20 | 0.53 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 2/20 | 0.53 |
| ▸ | GABRG3 known ✓ | Q99928 | 2/20 | 0.53 |
| ▸ | GABRQ known ✓ | Q9UN88 | 2/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Halazepam SCHEMBL7624840 | 0.95 | OPRK1 (0.68) | OPRK1NR1I2ADORA3OPRM1LMNA | |
| Lorazepam SCHEMBL4976540 | 0.91 | LMNA (0.65) | OPRK1LMNAPGRGABRA1GABRA5 | |
| Diazepam SCHEMBL10948878 | 0.87 | GABRA1 (0.69) | OPRK1NR1I2ADORA3OPRM1LMNA | |
| Quazepam SCHEMBL6524231 | 0.81 | LMNA (0.56) | OPRK1NR1I2ADORA3OPRM1LMNA | |
| Prazepam SCHEMBL7537961 | 0.80 | LMNA (0.64) | OPRK1NR1I2ADORA3OPRM1LMNA | |
| Lorazepam SCHEMBL4978513 | 0.80 | ADRA1A (0.51) | OPRK1LMNAPGRGABRA1GABRA5 | |
| Diazepam SCHEMBL1003950 | 0.79 | GABRA1 (0.70) | OPRK1LMNAGABRA1GABRA5GABRA2 | |
| Flunitrazepam SCHEMBL18316507 | 0.78 | GABRA1 (0.63) | OPRK1LMNAPGRGABRA1GABRA5 | |
| Halazepam SCHEMBL78995 | 0.78 | OPRK1 (1.00) | OPRK1NR1I2ADORA3OPRM1LMNA | |
| Lorazepam SCHEMBL3695725 | 0.78 | LMNA (0.89) | OPRK1LMNAPGRGABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912579-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998001450-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1998-01-15 | — | — | WO | disclosed |