Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | HTR6 | P50406 | 17/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530026 | 0.85 | CYP3A4 (0.52) | CYP3A4CYP2D6HTR6HTR2A | |
| SCHEMBL6527092 | 0.83 | CYP3A4 (1.00) | CYP3A4CYP2D6HTR6HTR2AL3MBTL1 | |
| SCHEMBL6530503 | 0.80 | CYP3A4 (0.83) | CYP3A4CYP2D6HTR6L3MBTL1 | |
| SCHEMBL6532617 | 0.78 | CYP3A4 (0.79) | CYP3A4CYP2D6HTR6L3MBTL1 | |
| SCHEMBL6529764 | 0.74 | HTR6 (0.61) | CYP3A4CYP2D6HTR6HTR2A | |
| SCHEMBL6529121 | 0.73 | CYP3A4 (0.74) | CYP3A4CYP2D6HTR6HTR2ADRD3 | |
| SCHEMBL6530751 | 0.70 | CYP3A4 (0.64) | CYP3A4CYP2D6HTR6HTR2A | |
| SCHEMBL6529490 | 0.68 | CYP3A4 (0.60) | CYP3A4CYP2D6HTR6HTR2A | |
| SCHEMBL6529028 | 0.67 | HTR6 (0.60) | CYP3A4CYP2D6HTR6HTR2A | |
| SCHEMBL6528108 | 0.67 | HTR6 (0.60) | CYP3A4CYP2D6HTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005066157-A1 | 3-(PYROLIDIN-3-L) INDOLES AS 5-HT6 RECEPTOR MODULATORS | SUVEN LIFE SCIENCES (IN) | 2005-07-21 | — | — | WO | claimed |
| WO-2005066157-A1 | 3-(PYROLIDIN-3-L) INDOLES AS 5-HT6 RECEPTOR MODULATORS | SUVEN LIFE SCIENCES (IN) | 2005-07-21 | — | — | WO | disclosed |