Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 3/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651079 | 0.93 | AGTR1 (0.34) | AGTR1ADORA3ADORA2BALDH1A1LMNA | |
| SCHEMBL652064 | 0.90 | ITGB1 (0.31) | EGFRBTKADORA3ADORA2B | |
| SCHEMBL652331 | 0.86 | DRD2 (0.35) | AGTR1ADORA2BDRD2TBXA2R | |
| SCHEMBL648189 | 0.85 | DRD2 (0.34) | AGTR1ADORA2BDRD2TBXA2R | |
| SCHEMBL651121 | 0.85 | MEN1 (0.34) | AGTR1ADORA2BDRD2TBXA2R | |
| SCHEMBL652770 | 0.85 | TLR8 (0.35) | AGTR1DRD2TBXA2RALDH1A1 | |
| SCHEMBL652578 | 0.84 | AGTR1 (0.34) | AGTR1DRD2TBXA2R | |
| SCHEMBL650291 | 0.83 | DRD2 (0.33) | AGTR1ADORA2BDRD2TBXA2R | |
| SCHEMBL651080 | 0.81 | MEN1 (0.38) | MERTKPDE7APDE4DAGTR1ALDH1A1 | |
| SCHEMBL648905 | 0.80 | RARA (0.35) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |