SCHEMBL6536500

SCHEMBL6536500

COc1ccc(C2(c3ccccc3F)C=Cc3ccccc3C2)cc1

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.34
OPRM1 P35372 1/20 0.34
OPRL1 P41146 1/20 0.34
KIF11 P52732 2/20 0.34
ALDH1A1 P00352 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
RELA Q04206 1/20 0.33
NFE2L2 Q16236 1/20 0.33
CHRM5 P08912 1/20 0.33
SIGMAR1 Q99720 3/20 0.33
MAOB P27338 2/20 0.33
MAOA P21397 1/20 0.33
LMNA P02545 1/20 0.31
POLB P06746 1/20 0.31
SLC6A3 Q01959 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6689248 0.87 HDAC9 (0.33) OPRM1KIF11ALDH1A1CHRM5
SCHEMBL8085651 0.86 PDK2 (0.35) CHRM5
SCHEMBL6689781 0.85 OPRM1 (0.32) OPRM1OPRL1
SCHEMBL9546931 0.84 MAOA (0.36) L3MBTL1MAOBMAOALMNA
SCHEMBL7455420 0.83 ACHE (0.37) ATMOPRM1OPRL1KIF11ALDH1A1
SCHEMBL9113335 0.81 MAPT (0.36) OPRM1OPRL1ALDH1A1LMNA
SCHEMBL5072171 0.80
SCHEMBL7972739 0.74 MAPT (0.43) ALDH1A1L3MBTL1SIGMAR1
SCHEMBL6689370 0.74 MAPT (0.35) ALDH1A1LMNAPOLB
SCHEMBL6536525 0.74 SMN1; SMN2 (0.34) ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1394595-B1 PLASTIC MOLDED PRODUCT HAVING PHOTOCHROMIC CHARACTERISTICS AND/OR POLARIZING CHARACTERISTICS MITSUBISHI GAS CHEMICAL CO (JP) 2013-05-01 EP disclosed
EP-1162482-B1 Synthetic resin laminate having both polarization characteristic and photochromism characteristic MITSUBISHI GAS CHEMICAL CO (JP) 2012-06-20 EP disclosed
US-6797383-B2 RESIN LAYER HAVING PHOTOCHROMISM CHARACTERISTIC AND RESIN LAYER HAVING POLARIZATION CHARACTERISTIC INTERPOSED BETWEEN TWO TRANSPARENT SYNTHETIC RESIN LAYERS, ADHESIVE LAYER; SUNGLASSES, SPORTS GOGGLES MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-09-28 US disclosed
EP-1273935-B1 TRANSPARENT SYNTHETIC RESIN LAMINATE HAVING PHOTOCHROMISM MITSUBISHI GAS CHEMICAL CO (JP) 2004-06-30 EP disclosed
EP-1273935-A1 TRANSPARENT SYNTHETIC RESIN LAMINATE HAVING PHOTOCHROMISM MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2003-01-08 EP disclosed
US-20020006505-A1 Synthetic resin laminate having both polariztion characteristic and photochromism characteristic MITSUBISHI GAS CHEMICAL COMPANY, INC. 2002-01-17 US disclosed
EP-1162482-A2 Synthetic resin laminate having both polarization characteristic and photochromism characteristic MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2001-12-12 EP disclosed