Sugi Predict

Sugi Predict / Compounds / SCHEMBL65369

SCHEMBL65369

SCHEMBL65369

Clc1ccccc1OCCBr

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 6/20 0.55
▸ MAPT P10636 3/20 0.53
▸ MEN1 O00255 1/20 0.53
▸ PKM P14618 1/20 0.53
▸ KMT2A Q03164 1/20 0.53
▸ TDP1 Q9NUW8 1/20 0.53
▸ TSHR P16473 1/20 0.51
▸ CYP1A2 P05177 2/20 0.50
▸ CYP2C19 P33261 2/20 0.50
▸ KCNH2 Q12809 1/20 0.50
▸ DRD2 P14416 1/20 0.50
▸ DRD4 P21917 1/20 0.50
▸ DRD3 P35462 1/20 0.50
▸ CYP2D6 P10635 1/20 0.50
▸ RAB9A P51151 5/20 0.49
▸ NPC1 O15118 4/20 0.49
▸ HPGD P15428 2/20 0.49
▸ ALDH1A1 P00352 1/20 0.47
▸ ALOX15 P16050 1/20 0.47
▸ MAPK1 P28482 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30617862 1.00 L3MBTL1 (0.55) L3MBTL1MAPTMEN1PKMKMT2A
SCHEMBL30674518 0.89 L3MBTL1 (0.56) L3MBTL1MAPTMEN1PKMKMT2A
SCHEMBL1942054 0.89 L3MBTL1 (0.56) L3MBTL1MAPTMEN1PKMKMT2A
SCHEMBL1283225 0.88 L3MBTL1 (0.59) L3MBTL1MAPTMEN1PKMKMT2A
SCHEMBL9808263 0.86 L3MBTL1 (0.68) L3MBTL1MAPTMEN1PKMKMT2A
SCHEMBL29755815 0.84 KDM4E (0.54) L3MBTL1MAPTTDP1CYP1A2CYP2C19
SCHEMBL6795825 0.84 KDM4E (0.54) L3MBTL1MAPTTDP1CYP1A2CYP2C19
SCHEMBL2206657 0.83 ALDH1A1 (0.54) L3MBTL1MAPTMEN1PKMKMT2A
SCHEMBL4486850 0.82 L3MBTL1 (0.48) L3MBTL1MAPTMEN1PKMKMT2A
SCHEMBL5660214 0.80 L3MBTL1 (0.59) L3MBTL1MAPTMEN1PKMKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117105872-A Benzodiazepine compound and preparation method and application thereof 徐州医科大学 2023-11-24 — — CN claimed
US-20050176700-A1 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension,cardiovascular or renal diseases ACTELION PHARMACEUTICALS LTD. (CH) 2005-08-11 — — US claimed
EP-3233077-B1 DOPAMINE D2 RECEPTOR LIGANDS BROAD INST INC (US) 2026-05-06 — — EP disclosed
US-12428373-B2 Dopamine D2 receptor ligands THE BROAD INSTITUTE, INC. (US) 2025-09-30 — — US disclosed
EP-4464703-A2 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF Gilead Sciences, Inc. (US) 2024-11-20 — — EP disclosed
EP-4245756-B1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF GILEAD SCIENCES INC (US) 2024-10-09 — — EP disclosed
US-11897862-B2 IKAROS zinc finger family degraders and uses thereof GILEAD SCIENCES, INC. (US) 2024-02-13 — — US disclosed
CN-117105872-A Benzodiazepine compound and preparation method and application thereof 徐州医科大学 2023-11-24 — — CN disclosed
US-20230373950-A1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF GILEAD SCIENCES, INC. 2023-11-23 — — US disclosed
US-20230295111-A1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF GILEAD SCIENCES, INC. 2023-09-21 — — US disclosed
EP-4245756-A1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF Gilead Sciences, Inc. (US) 2023-09-20 — — EP disclosed
WO-1998010286-A1 METHODS FOR PROCESSING CHEMICAL COMPOUNDS HAVING REACTIVE FUNCTIONAL GROUPS ISIS PHARMACEUTICALS, INC. (US) 1998-03-12 — — WO disclosed
EP-0817787-A1 NITROGENOUS MACROCYCLIC COMPOUNDS ISIS PHARMACEUTICALS, INC. (US) 1998-01-14 — — EP disclosed
WO-1996030377-A1 NITROGENOUS MACROCYCLIC COMPOUNDS ISIS PHARMACEUTICALS, INC. (US) 1996-10-03 — — WO disclosed
EP-0445026-B1 Aminomethylpiperidine derivatives, their process for preparation and the pharmaceutical compositions containing them ADIR (FR) 1994-01-26 — — EP disclosed
US-5229399-A Analgesics ADIR ET COMPAGNIE (FR) 1993-07-20 — — US disclosed
US-5229398-A Analgesics ADIR ET COMPAGNIE (FR) 1993-07-20 — — US disclosed
US-5192775-A Analgesics ADIR ET COMPAGNIE (FR) 1993-03-09 — — US disclosed
EP-0445026-A1 Aminomethylpiperidine derivatives, their process for preparation and the pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1991-09-04 — — EP disclosed
EP-0244641-B1 1,4-CYCLOHEXANE DIAMINES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES BASF Aktiengesellschaft (DE) 1991-08-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230373950-A1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF IKZF2, IKZF1, IKZF3 L3MBTL1 909/4885MAPT 2658/4885MEN1 2725/4885
US-20050176700-A1 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension,cardiovascular or renal diseases REN, AGTR1, ACE L3MBTL1 4871/4885MAPT 4578/4885MEN1 2389/4885
US-12428373-B2 Dopamine D2 receptor ligands DRD2, SLC6A3, NTSR2 L3MBTL1 1719/4885MAPT 1596/4885MEN1 4490/4885
US-11897862-B2 IKAROS zinc finger family degraders and uses thereof IKZF2, IKZF1, IKZF3 L3MBTL1 909/4885MAPT 2658/4885MEN1 2725/4885
US-20230295111-A1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF IKZF2, IKZF1, IKZF3 L3MBTL1 909/4885MAPT 2658/4885MEN1 2725/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.