Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL8185592 | 0.94 | — | — | |
| Histidine SCHEMBL6544571 | 0.93 | — | — | |
| Histidine SCHEMBL6554680 | 0.83 | — | — | |
| Histidine SCHEMBL8084688 | 0.81 | — | — | |
| Histidine SCHEMBL6511983 | 0.80 | ITGB3 (0.32) | — | |
| Histidine SCHEMBL1896523 | 0.80 | REN (0.32) | — | |
| Tyrosine SCHEMBL8185595 | 0.79 | F2 (0.35) | — | |
| Phenylalanine SCHEMBL3254715 | 0.78 | REN (0.31) | — | |
| Tryptophan SCHEMBL3252504 | 0.76 | GLP1R (0.32) | — | |
| Asparagine SCHEMBL3252545 | 0.76 | REN (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1034187-B1 | GROWTH-PROMOTING PROTEINS AND PEPTIDES FOR KIDNEY EPITHELIAL CELLS | ARCH DEV CORP (US) | 2004-01-07 | — | — | EP | claimed |