Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | SCN4A | P35499 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5309684 | 0.73 | ALPL (0.44) | ALDH1A1PARP10ALOX15MTNR1AMTNR1B | |
| SCHEMBL12468595 | 0.69 | PARP10 (0.39) | ALDH1A1PARP10BCAT2MEN1KMT2A | |
| SCHEMBL1078041 | 0.68 | ALDH1A1 (0.43) | ALDH1A1PARP10NPC1RAB9A | |
| SCHEMBL12099900 | 0.67 | PKM (0.39) | ALDH1A1PARP10MEN1KMT2APKM | |
| SCHEMBL1019370 | 0.66 | ALOX15 (0.50) | ALDH1A1PARP10MEN1KMT2ACYP1A2 | |
| SCHEMBL27650813 | 0.65 | ALOX15 (0.46) | ALDH1A1PARP10MEN1KMT2ACYP1A2 | |
| SCHEMBL8468005 | 0.65 | ALOX15 (0.48) | ALDH1A1PARP10MEN1KMT2ACYP1A2 | |
| SCHEMBL3465226 | 0.63 | PPARA (0.47) | ALDH1A1ALOX15PKMMTNR1AMTNR1B | |
| SCHEMBL2517194 | 0.63 | ALDH1A1 (0.60) | ALDH1A1PARP10ALOX15PKMMTNR1A | |
| SCHEMBL5724626 | 0.62 | PPARA (0.58) | CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372627-A1 | USE OF BREAKERS OF ADVANCED GLYCATION ENDPRODUCTS FOR TREATING DELETERIOUS EFFECTS OF AGING AND DEBILITATING DISEASES | CITY OF HOPE (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002076443-A1 | USE OF BREAKERS OF ADVANCED GLYCATION ENDPRODUCTS FOR TREATING DELETERIOUS EFFECTS OF AGING AND DEBILITATING DISEASES | CITY OF HOPE (US) | 2002-10-03 | — | — | WO | disclosed |