Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PPIA | P62937 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16568994 | 0.89 | L3MBTL1 (0.53) | L3MBTL1RAB9ANPC1LMNAMEN1 | |
| SCHEMBL12099902 | 0.87 | DHODH (0.56) | L3MBTL1RAB9ANPC1LMNAMEN1 | |
| SCHEMBL9561356 | 0.83 | MAPT (0.67) | L3MBTL1RAB9ANPC1LMNAMEN1 | |
| SCHEMBL5309687 | 0.81 | ALDH1A1 (0.54) | L3MBTL1RAB9ALMNAMAPTKMT2A | |
| SCHEMBL1046455 | 0.80 | ALDH1A1 (0.60) | L3MBTL1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL29195871 | 0.79 | ALDH1A1 (0.58) | L3MBTL1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL14975400 | 0.78 | NPC1 (0.61) | L3MBTL1RAB9ANPC1LMNAMEN1 | |
| SCHEMBL12017475 | 0.77 | KDM4E (0.57) | L3MBTL1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL10458447 | 0.76 | KDM4E (0.72) | RAB9ANPC1LMNAMEN1MAPT | |
| SCHEMBL14976588 | 0.75 | L3MBTL1 (0.62) | L3MBTL1RAB9ANPC1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372627-A1 | USE OF BREAKERS OF ADVANCED GLYCATION ENDPRODUCTS FOR TREATING DELETERIOUS EFFECTS OF AGING AND DEBILITATING DISEASES | CITY OF HOPE (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002076443-A1 | USE OF BREAKERS OF ADVANCED GLYCATION ENDPRODUCTS FOR TREATING DELETERIOUS EFFECTS OF AGING AND DEBILITATING DISEASES | CITY OF HOPE (US) | 2002-10-03 | — | — | WO | disclosed |