Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 8/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.37 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2861586 | 0.78 | MAP2K4 (0.56) | MAP2K4HTR7GRK6NOTUM | |
| SCHEMBL2858263 | 0.77 | HTR7 (0.44) | MAP2K4HTR7NOTUMMAP4K4 | |
| SCHEMBL13636072 | 0.74 | HTR7 (0.44) | MAP2K4HTR7NOTUM | |
| SCHEMBL2863255 | 0.74 | TTK (0.47) | MAP2K4MAP2K7 | |
| SCHEMBL4334510 | 0.73 | MAPK1 (0.39) | MAP2K4MAP2K7 | |
| SCHEMBL2868575 | 0.72 | POLB (0.45) | CCNA2CDK2CCNA1 | |
| SCHEMBL4334123 | 0.72 | ROCK2 (0.43) | MAP2K4 | |
| SCHEMBL15782613 | 0.72 | ICMT (0.55) | ICMT | |
| SCHEMBL2859630 | 0.71 | HTR7 (0.44) | MAP2K4HTR7NOTUM | |
| SCHEMBL2861096 | 0.71 | MAP2K4 (0.51) | MAP2K4GRK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-A1 | NOVEL 1H-INDAZOLE COMPOUND | Eisai Co., Ltd. (JP) | 2004-01-14 | — | — | EP | disclosed |