Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89548 | 0.86 | ALDH1A1 (0.50) | KDM4EPTPN1ALDH1A1TSHRHPGD | |
| SCHEMBL278676 | 0.84 | PTPN1 (0.47) | KDM4EPTPN1ALDH1A1TSHRHPGD | |
| SCHEMBL11120806 | 0.83 | KDM4E (0.38) | KDM4EPTPN1ALDH1A1TSHRHPGD | |
| Hydrochloric Acid SCHEMBL27897977 | 0.83 | PTPN1 (0.46) | KDM4EPTPN1ALDH1A1TSHRHPGD | |
| SCHEMBL21084683 | 0.83 | PTPN1 (0.44) | KDM4EPTPN1ALDH1A1TSHRHPGD | |
| SCHEMBL10692029 | 0.80 | PTPN1 (0.43) | KDM4EPTPN1ALDH1A1TSHRHPGD | |
| SCHEMBL83996 | 0.80 | AKR1C3 (0.46) | PTPN1ALDH1A1TSHRHPGDMAPT | |
| Benzophenone SCHEMBL27852184 | 0.79 | ALDH1A1 (0.45) | PTPN1ALDH1A1TSHRHPGDMAPT | |
| SCHEMBL11767364 | 0.79 | AKR1C3 (0.44) | KDM4EPTPN1ALDH1A1TSHRMAPT | |
| SCHEMBL8946208 | 0.79 | CYP1A2 (0.41) | KDM4EPTPN1ALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738138-A1 | QUATERNARY SALTS OF PARA-DIALKYLAMINO BENZAMIDE DERIVATIVES | ISP Van Dyk Inc. (US) | 1996-10-23 | — | — | EP | claimed |
| EP-0738138-A4 | QUATERNARY SALTS OF PARA-DIALKYLAMINO BENZAMIDE DERIVATIVES | ISP VAN DYK INC (US) | 1996-07-08 | — | — | EP | claimed |
| WO-1995005797-A1 | QUATERNARY SALTS OF PARA-DIALKYLAMINO BENZAMIDE DERIVATIVES | ISP VAN DYK INC. (US) | 1995-03-02 | — | — | WO | claimed |
| CN-109180394-A | A kind of granular urea preparation method containing alginic acid synergistic carrier suitable for winter wheat top dressing | 中国农业科学院农业资源与农业区划研究所 | 2019-01-11 | — | — | CN | disclosed |
| EP-2013196-B1 | DISUBSTITUTED ANILINE COMPOUNDS | MERCK SHARP & DOHME (US) | 2015-09-16 | — | — | EP | disclosed |
| US-8119685-B2 | Disubstituted aniline compounds | MERCK SHARP & DOHME CORP. (US) | 2012-02-21 | — | — | US | disclosed |
| US-20090221669-A1 | Disubstituted Aniline Compounds | MERCK SHARP & DOHME LLC | 2009-09-03 | — | — | US | disclosed |
| EP-2013196-A2 | DISUBSTITUTED ANILINE COMPOUNDS | Merck & Co., Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007127137-A2 | DISUBSTITUTED ANILINE COMPOUNDS | MERCK & CO., INC. (US) | 2007-11-08 | — | — | WO | disclosed |
| US-5427773-A | Sunscreen agents | ISP VAN DYK INC. (US) | 1995-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221669-A1 | Disubstituted Aniline Compounds | TXNRD2, BRDT, HDAC1 | KDM4E 500/4885PTPN1 1085/4885ALDH1A1 744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.