Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.30 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.30 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | GPR3 | P46089 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8984050 | 0.77 | GPR3 (0.32) | GPR3HTR2A | |
| Hydrochloric Acid SCHEMBL4079003 | 0.76 | GPR3 (0.35) | GPR3HTR2APOLB | |
| Ethane SCHEMBL8174121 | 0.75 | GPR3 (0.46) | GPR3HTR2APOLBSLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL540484 | 0.75 | GPR3 (0.44) | GPR3HTR2APOLBSLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL6553648 | 0.74 | GPR3 (0.35) | GPR3HTR2APOLBSLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL7944464 | 0.73 | GPR3 (0.42) | GPR3HTR2APOLBSLC6A2SLC6A4 | |
| Toluene SCHEMBL27459088 | 0.72 | LMNA (0.48) | GPR3HTR2APOLBSLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8364165 | 0.70 | LMNA (0.32) | — | |
| Hydrochloric Acid SCHEMBL7270000 | 0.68 | GPR3 (0.36) | GPR3HTR2AACHE | |
| Hydrochloric Acid SCHEMBL7251524 | 0.68 | MYC (0.38) | GPR3HTR2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077215-B1 | Asymmetric silicon-bridged metallocenes useful as catalysts in the polymerization of a-olefins, process for their preparation and use of said metallocenes for the polymerization of a-olefins | SOLVAY (BE) | 2004-02-18 | — | — | EP | disclosed |
| EP-1077215-A1 | Asymmetric silicon-bridged metallocenes useful as catalysts in the polymerization of a-olefins, process for their preparation and use of said metallocenes for the polymerization of a-olefins | SOLVAY POLYOLEFINS EUROPE - BELGIUM (Société Anonyme) (BE) | 2001-02-21 | — | — | EP | disclosed |