SCHEMBL6555090

SCHEMBL6555090

Cc1cccc([SiH2]Cc2ccc(C(C)(C)C)c(S)c2C(C)(C)C)c1C

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.31
GABRB2 P47870 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8038880 0.77 GABRA1 (0.33) GABRA1GABRB2
SCHEMBL5692154 0.66 GABRA1 (0.41) GABRA1GABRB2
SCHEMBL5354598 0.66 GABRA1 (0.34) GABRA1GABRB2
SCHEMBL7521592 0.65 ALOX15 (0.39) GABRA1GABRB2
SCHEMBL2555602 0.64 GABRA1 (0.56) GABRA1GABRB2
SCHEMBL9217674 0.64 TRPA1 (0.41)
SCHEMBL988672 0.64 POLB (0.37)
SCHEMBL10440548 0.62 TRPA1 (0.39)
SCHEMBL6676515 0.61 SCN2A (0.43) GABRA1GABRB2
SCHEMBL5692120 0.61 NR1H2 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0732928-B1 METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS MERRELL PHARMA INC (US) 2004-12-22 EP claimed