SCHEMBL6557586

SCHEMBL6557586

CCC(=O)Oc1c(OCc2ccccc2)cccc1OCc1nc2ccccc2c(=O)n1C

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.52
ALOX15 P16050 1/20 0.52
TSHR P16473 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
ACKR3 P25106 6/20 0.50
HSD17B10 Q99714 1/20 0.50
HDAC6 Q9UBN7 2/20 0.48
USP2 O75604 1/20 0.47
RAB9A P51151 1/20 0.47
PPARG P37231 1/20 0.46
HDAC8 Q9BY41 1/20 0.45
ALDH1A1 P00352 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HIF1A Q16665 1/20 0.42
PDE10A Q9Y233 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6555842 0.94 TSHR (0.52) KDM4EALOX15TSHRTDP1L3MBTL1
SCHEMBL6557988 0.93 L3MBTL1 (0.51) KDM4EALOX15TSHRTDP1L3MBTL1
SCHEMBL6557322 0.91 KDM4E (0.52) KDM4EALOX15TSHRTDP1L3MBTL1
SCHEMBL6556016 0.91 L3MBTL1 (0.51) KDM4EALOX15TSHRTDP1L3MBTL1
SCHEMBL6557964 0.90 ACKR3 (0.52) KDM4EALOX15TSHRTDP1L3MBTL1
SCHEMBL6555584 0.84 PDE4A (0.50) KDM4ETSHRHSD17B10USP2RAB9A
SCHEMBL6557887 0.82 HTR7 (0.51) HSD17B10USP2RAB9AALDH1A1SMN1; SMN2
SCHEMBL6555779 0.81 TNF (0.42) KDM4EALOX15TSHRTDP1L3MBTL1
SCHEMBL6555790 0.79 MEN1 (0.52) HSD17B10USP2RAB9AALDH1A1SMN1; SMN2
SCHEMBL6557412 0.78 PDE10A (0.57) USP2ALDH1A1PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1073643-B1 NEW HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM REDDYS LAB LTD DR (IN) 2004-12-29 EP claimed
EP-1073643-B1 NEW HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM REDDYS LAB LTD DR (IN) 2004-12-29 EP disclosed
EP-1073643-A2 NEW HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 2001-02-07 EP disclosed
WO-1999008501-A2 NEW HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 1999-02-25 WO disclosed