Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 4/20 | 0.48 |
| ▸ | MMP13 | P45452 | 3/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP14 | P50281 | 2/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.47 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557780 | 0.88 | MMP2 (0.61) | ALDH1A1MMP1MMP13ADAMTS4MMP2 | |
| SCHEMBL6557790 | 0.85 | MMP1 (0.50) | ALDH1A1HPGDPKMALOX12MMP1 | |
| SCHEMBL5445643 | 0.79 | ALDH1A1 (0.51) | ALDH1A1HPGDPKMALOX12MMP1 | |
| SCHEMBL5445650 | 0.79 | ALDH1A1 (0.48) | ALDH1A1HPGDPKMALOX12MMP1 | |
| SCHEMBL14565748 | 0.76 | ALDH1A1 (0.46) | ALDH1A1HPGDPKMALOX12MMP1 | |
| SCHEMBL6558721 | 0.72 | TBXAS1 (0.49) | ALDH1A1PKMMMP1MMP13ADAMTS4 | |
| SCHEMBL6558726 | 0.72 | TBXAS1 (0.49) | ALDH1A1PKMMMP1MMP13ADAMTS4 | |
| SCHEMBL6557782 | 0.71 | MMP2 (0.64) | ALDH1A1MMP1MMP13ADAMTS4MMP2 | |
| SCHEMBL6558732 | 0.71 | MMP1 (0.50) | ALDH1A1HPGDMMP1MMP13ADAMTS4 | |
| SCHEMBL11888420 | 0.69 | LMNA (0.47) | ALDH1A1MMP1MMP13MMP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436255-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2004-07-14 | — | — | EP | claimed |
| WO-2003024924-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2003-03-27 | — | — | WO | claimed |