Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.61 |
| ▸ | CA1 | P00915 | 4/20 | 0.61 |
| ▸ | CA2 | P00918 | 4/20 | 0.61 |
| ▸ | CA7 | P43166 | 4/20 | 0.61 |
| ▸ | CA9 | Q16790 | 4/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.61 |
| ▸ | PNMT | P11086 | 6/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4107613 | 0.90 | MTNR1A (0.62) | CA12CA1CA2CA7CA9 | |
| SCHEMBL4107609 | 0.90 | MTNR1A (0.62) | CA12CA1CA2CA7CA9 | |
| SCHEMBL27744228 | 0.86 | ADRA2A (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL8008337 | 0.85 | CA1 (0.59) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3803914 | 0.85 | CA1 (0.59) | CA12CA1CA2CA7CA9 | |
| SCHEMBL8370641 | 0.83 | PNMT (0.49) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL4108185 | 0.83 | MTNR1A (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1415332 | 0.82 | PNMT (0.49) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL6560917 | 0.80 | GAA (0.54) | CA12CA1CA2CA7CA9 | |
| SCHEMBL6202191 | 0.79 | DRD2 (0.58) | CA12CA1CA2CA7CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091946-B1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2004-03-17 | — | — | EP | disclosed |
| CN-1126747-C | 2-aminothiazole-fused 2-aminoindanes and 2-aminotetralines and their use | HECKEN VILHELM WIKSTROHM (NL) | 2003-11-05 | — | — | CN | disclosed |
| US-6291494-B1 | 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |
| CN-1307569-A | 2-aminothiazole-fused 2-aminoindanes and 2-aminotetralines and their use | HECKEN VILKELM WIKSTROHM (NL) | 2001-08-08 | — | — | CN | disclosed |
| EP-1091946-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTRÖM, Hakan Vilhelm (NL) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001680-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2000-01-13 | — | — | WO | disclosed |