Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 4/20 | 0.47 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 14/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559271 | 0.86 | KCNE1 (0.61) | KCNE1KCNQ1TRPV1CYP3A4AKR1B1 | |
| SCHEMBL6559550 | 0.83 | MEN1 (0.37) | KCNE1KCNQ1AKR1B1 | |
| SCHEMBL6559957 | 0.82 | KCNE1 (0.50) | KCNE1KCNQ1CYP3A4 | |
| SCHEMBL6558778 | 0.81 | HTR1A (0.36) | KCNE1KCNQ1 | |
| SCHEMBL6559569 | 0.79 | RAB9A (0.37) | — | |
| SCHEMBL6559266 | 0.79 | KCNE1 (0.52) | KCNE1KCNQ1TRPV1CYP3A4AKR1B1 | |
| SCHEMBL6560815 | 0.77 | TRPV1 (0.48) | KCNE1KCNQ1TRPV1CYP3A4CFTR | |
| SCHEMBL6558722 | 0.75 | KCNE1 (0.48) | KCNE1KCNQ1TRPV1CYP3A4AKR1B1 | |
| SCHEMBL8477514 | 0.75 | KCNE1 (0.50) | KCNE1KCNQ1TRPV1CYP3A4CFTR | |
| SCHEMBL7468526 | 0.74 | KCNE1 (0.49) | KCNE1KCNQ1TRPV1CYP3A4AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |