Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | POLR1A | O95602 | 3/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 3/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.35 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.35 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5185602 | 0.90 | CASP3 (0.35) | HTTCHEK1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1095842 | 0.86 | ALOX5 (0.39) | HTTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2524404 | 0.86 | ALOX5 (0.39) | HTTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL9511404 | 0.86 | KDM4E (0.38) | HTTSMN1; SMN2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5187338 | 0.85 | ALDH1A1 (0.41) | SMN1; SMN2CHEK1ALDH1A1KDM4E | |
| SCHEMBL5577030 | 0.83 | HTT (0.36) | HTTSMN1; SMN2HSD17B10 | |
| SCHEMBL5576815 | 0.83 | TP53 (0.40) | SMN1; SMN2KDM4E | |
| SCHEMBL2683123 | 0.81 | CHEK1 (0.31) | CHEK1 | |
| SCHEMBL10341193 | 0.81 | CHEK1 (0.47) | CHEK1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5575192 | 0.79 | HTT (0.47) | HTTCHEK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040229894-A1 | Inhibition of human teomerase by a G-quadruplex-interaction compound | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2004-11-18 | — | — | US | claimed |
| US-20030040525-A1 | Inhibition of human telomerase by a G-quadruplex-interaction compound | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2003-02-27 | — | — | US | claimed |
| US-20020107258-A1 | Inhibition of human telomerase by a G-quadruplex-interaction compound | BOARD OF REGENTS, THE UNIVERSTY OF TEXAS SYSTEM | 2002-08-08 | — | — | US | claimed |
| US-6156763-A | Inhibition of human telomerase by a g-quadruplex-interaction compound | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-12-05 | — | — | US | claimed |
| EP-1053237-A2 | INHIBITION OF HUMAN TELOMERASE BY A G-QUADRUPLEX-INTERACTION COMPOUND | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-11-22 | — | — | EP | claimed |
| WO-1999040087-A2 | INHIBITION OF HUMAN TELOMERASE BY A G-QUADRUPLEX-INTERACTION COMPOUND | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1999-08-12 | — | — | WO | claimed |
| US-20040229894-A1 | Inhibition of human teomerase by a G-quadruplex-interaction compound | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2004-11-18 | — | — | US | disclosed |
| US-6689887-B2 | PERYLENETETRACARBOXYLIC ACID DIIMIDES AND CARBOCYANINES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2004-02-10 | — | — | US | disclosed |
| US-6623930-B2 | Contacting cell with non-nucleoside compounds that interact with specific DNA structures and which inhibit human telomerase reducing proliferative capacity of a cell | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2003-09-23 | — | — | US | disclosed |
| EP-1053237-B1 | INHIBITION OF HUMAN TELOMERASE BY A G-QUADRUPLEX-INTERACTION COMPOUND | UNIV TEXAS (US) | 2003-07-02 | — | — | EP | disclosed |
| US-6528517-B1 | Solid phase synthesis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2003-03-04 | — | — | US | disclosed |
| US-20030040525-A1 | Inhibition of human telomerase by a G-quadruplex-interaction compound | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2003-02-27 | — | — | US | disclosed |
| US-20020107258-A1 | Inhibition of human telomerase by a G-quadruplex-interaction compound | BOARD OF REGENTS, THE UNIVERSTY OF TEXAS SYSTEM | 2002-08-08 | — | — | US | disclosed |
| US-6156763-A | Inhibition of human telomerase by a g-quadruplex-interaction compound | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-12-05 | — | — | US | disclosed |
| EP-1053237-A2 | INHIBITION OF HUMAN TELOMERASE BY A G-QUADRUPLEX-INTERACTION COMPOUND | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-11-22 | — | — | EP | disclosed |
| WO-1999040087-A2 | INHIBITION OF HUMAN TELOMERASE BY A G-QUADRUPLEX-INTERACTION COMPOUND | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1999-08-12 | — | — | WO | disclosed |
| WO-1999040093-A2 | SYNTHESIS OF QUINOBENZOXAZINE ANALOGUES WITH TOPOISOMERASE II AND QUADRUPLEX INTERACTIONS FOR USE AS ANTINEOPLASTIC AGENTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1999-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030040525-A1 | Inhibition of human telomerase by a G-quadruplex-interaction compound | POT1, TERT, TERF2IP | HTT 93/4885SMN1; SMN2 1414/4885JAK2 3317/4885 |
| US-20020107258-A1 | Inhibition of human telomerase by a G-quadruplex-interaction compound | POT1, TERT, TERF2IP | HTT 93/4885SMN1; SMN2 1414/4885JAK2 3317/4885 |
| US-20040229894-A1 | Inhibition of human teomerase by a G-quadruplex-interaction compound | TERT, POT1, DTYMK | HTT 1618/4885SMN1; SMN2 2292/4885JAK2 3926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.