Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 16/20 | 0.55 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.55 |
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5719575 | 1.00 | ITGA4 (0.55) | ITGA4ITGB1LTA4HPPARGPTGS2 | |
| Hydrochloric Acid SCHEMBL6509920 | 0.99 | ITGA4 (0.54) | ITGA4ITGB1LTA4HPPARGPTGS2 | |
| SCHEMBL23387525 | 0.92 | ITGA4 (0.48) | ITGA4ITGB1LTA4H | |
| SCHEMBL15105296 | 0.92 | ITGA4 (0.48) | ITGA4ITGB1LTA4H | |
| SCHEMBL31070921 | 0.92 | ITGA4 (0.48) | ITGA4ITGB1LTA4H | |
| SCHEMBL5719932 | 0.89 | ITGA4 (0.50) | ITGA4ITGB1LTA4H | |
| SCHEMBL5719938 | 0.89 | ITGA4 (0.50) | ITGA4ITGB1LTA4H | |
| SCHEMBL7709191 | 0.88 | LTA4H (0.49) | ITGA4ITGB1LTA4H | |
| SCHEMBL5719732 | 0.87 | ITGA4 (0.48) | ITGA4ITGB1LTA4H | |
| Hydrochloric Acid SCHEMBL6510340 | 0.87 | LTA4H (0.46) | ITGA4ITGB1LTA4HPPARGPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144365-B1 | INHIBITORS OF ALPHA-4 BETA-1 MEDIATED CELL ADHESION | TANABE SEIYAKU CO (JP) | 2004-03-17 | — | — | EP | disclosed |
| EP-0991619-B1 | INHIBITORS OF ALPHA 4-BETA 1 MEDIATED CELL ADHESION | TANABE SEIYAKU CO (JP) | 2003-09-10 | — | — | EP | disclosed |
| US-6596752-B1 | Small molecules that are potent inhibitors of alpha 4 beta 1 mediated adhesion to either VCAM or CS-1 and which could be useful for the treatment of inflammatory diseases. | TANABE SEIYAKU CO., LTD. (JP) | 2003-07-22 | — | — | US | disclosed |
| US-20030130349-A1 | Inhibitors of alpha 4beta1 mediated cell adhesion | TANABE SEIYAKU CO., LTD. | 2003-07-10 | — | — | US | disclosed |
| US-6482849-B1 | Inhibitors of α4β1 mediated cell adhesion | TANABE SEIYAKU CO., LTD. (JP) | 2002-11-19 | — | — | US | disclosed |
| US-20020035127-A1 | Phenylalanine derivatives | CELLTECH THERAPEUTIS, LIMITED | 2002-03-21 | — | — | US | disclosed |
| US-6329372-B1 | HETEROCYCLIC AMIDE COMPOUNDS ARE ABLE TO INHIBIT THE BINDING OF ALPHA4 INTEGRINS TO THEIR LIGANDS AND ARE OF USE IN THE PROPHYLAXIS AND TREATMENT OF IMMUNE OR INFLAMMATORY DISORDERS. | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |
| US-6197794-B1 | ANTIINFLAMAMTORY AGENTS; IMMUNOLOGY DISEASES | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020035127-A1 | Phenylalanine derivatives | PAH, VCAM1, IL4I1 | ITGA4 5/4885ITGB1 8/4885LTA4H 112/4885 |
| US-20030130349-A1 | Inhibitors of alpha 4beta1 mediated cell adhesion | VCAM1, ICAM1, ITGB1 | ITGA4 8/4885ITGB1 3/4885LTA4H 978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.