Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL540062 | 0.95 | PKM (0.64) | PKMTSHRKMT2AALDH1A1MEN1 | |
| SCHEMBL7652825 | 0.86 | LMNA (0.54) | PKMTSHRALDH1A1MAPTGAA | |
| SCHEMBL7652722 | 0.84 | LMNA (0.53) | PKMTSHRKMT2AALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL7654927 | 0.83 | PKM (0.58) | PKMTSHRKMT2AALDH1A1MEN1 | |
| SCHEMBL17902921 | 0.81 | ALDH1A1 (0.63) | TSHRALDH1A1USP2KDM4ECYP1A2 | |
| SCHEMBL17899709 | 0.81 | KMT2A (0.50) | TSHRKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL3176219 | 0.80 | LMNA (0.59) | PKMTSHRALDH1A1MAPTKDM4E | |
| SCHEMBL9581858 | 0.78 | LMNA (0.58) | PKMTSHRKMT2AALDH1A1MEN1 | |
| SCHEMBL9582446 | 0.78 | LMNA (0.58) | PKMTSHRKMT2AALDH1A1MEN1 | |
| SCHEMBL17902923 | 0.78 | KDM4E (0.53) | KMT2AALDH1A1MAPTGAACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016107541-A1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | 成都先导药物开发有限公司 | 2016-07-07 | — | — | WO | disclosed |
| WO-2016107544-A1 | INTERMEDIATE COMPOUND FOR PREPARING PYRROLE AMIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF | 成都先导药物开发有限公司 | 2016-07-07 | — | — | WO | disclosed |
| CN-105732459-A | Pyrrole amide compounds, preparation method and applications thereof | 成都先导药物开发有限公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-105732597-A | Intermediate compounds for preparing pyrrole amide compounds, preparation method and applications thereof | 成都先导药物开发有限公司 | 2016-07-06 | — | — | CN | disclosed |
| EP-1124797-B1 | N-ARYLSULFONYL AMINO ACID OMEGA AMIDES | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6339092-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS | ADIR ET COMPAGNIE (FR) | 2002-01-15 | — | — | US | disclosed |
| US-6335333-B1 | MATRIX METALLOPROTEINASE INHIBITORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-01 | — | — | US | disclosed |
| EP-1124797-A1 | N-ARYLSULFONYL AMINO ACID OMEGA AMIDES | Aventis Pharma Deutschland GmbH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-6201130-B1 | FOR THE THERAPY AND PROPHYLAXIS OF DISORDERS INVOLVING MATRIX-DEGRADING METALLOPROTEINASES; ANTIINFLAMMATORY AGENTS | AVENTIS PHARMA DUETSCHLAND GMBH (DE) | 2001-03-13 | — | — | US | disclosed |
| WO-2000027808-A1 | N-ARYLSULFONYL AMINO ACID OMEGA AMIDES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-05-18 | — | — | WO | disclosed |