Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.44 |
| ▸ | CHKA | P35790 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652722 | 0.98 | LMNA (0.53) | LMNASMN1; SMN2MAPK1HTTMMP3 | |
| SCHEMBL3176219 | 0.94 | LMNA (0.59) | LMNASMN1; SMN2MAPK1HTTMAPT | |
| SCHEMBL9582446 | 0.92 | LMNA (0.58) | LMNASMN1; SMN2MAPK1HTTMAPT | |
| SCHEMBL9581858 | 0.92 | LMNA (0.58) | LMNASMN1; SMN2MAPK1HTTMAPT | |
| SCHEMBL6561315 | 0.86 | PKM (0.58) | HTTMAPTALDH1A1PKMTSHR | |
| SCHEMBL17902921 | 0.84 | ALDH1A1 (0.63) | LMNAHTTALDH1A1TSHRHTR6 | |
| SCHEMBL17899709 | 0.84 | KMT2A (0.50) | SMN1; SMN2HTTMAPTALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL7652831 | 0.81 | LMNA (0.54) | LMNASMN1; SMN2MAPK1HTTMMP3 | |
| SCHEMBL8517012 | 0.81 | LMNA (0.64) | LMNASMN1; SMN2MAPK1HTTALDH1A1 | |
| SCHEMBL17902923 | 0.80 | KDM4E (0.53) | SMN1; SMN2MAPTALDH1A1CHKAHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339092-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS | ADIR ET COMPAGNIE (FR) | 2002-01-15 | — | — | US | disclosed |
| US-6335333-B1 | MATRIX METALLOPROTEINASE INHIBITORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-01 | — | — | US | disclosed |
| US-6201130-B1 | FOR THE THERAPY AND PROPHYLAXIS OF DISORDERS INVOLVING MATRIX-DEGRADING METALLOPROTEINASES; ANTIINFLAMMATORY AGENTS | AVENTIS PHARMA DUETSCHLAND GMBH (DE) | 2001-03-13 | — | — | US | disclosed |