Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562122 | 0.88 | ALOX15 (0.54) | TSHRALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL6563188 | 0.84 | KEAP1 (0.49) | TSHRALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL6563185 | 0.84 | TDP1 (0.53) | ALDH1A1L3MBTL1LMNAKDM4EKMT2A | |
| SCHEMBL6563164 | 0.78 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1LMNAKDM4EKMT2A | |
| SCHEMBL6561737 | 0.78 | KEAP1 (0.49) | TSHRALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL6561650 | 0.78 | KEAP1 (0.53) | TSHRALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL8625192 | 0.77 | F10 (0.67) | ALDH1A1L3MBTL1LMNAKDM4EKMT2A | |
| SCHEMBL6561679 | 0.77 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1LMNAKDM4EKMT2A | |
| SCHEMBL328337 | 0.76 | ALDH1A1 (0.74) | TSHRALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL8626109 | 0.76 | CCR9 (0.66) | KMT2AHPGDMEN1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990645-B1 | NOVEL SULFONAMIDE DERIVATIVES | NIPPON KAYAKU KK (JP) | 2004-07-28 | — | — | EP | disclosed |
| US-6180796-B1 | TUBULIN POLYMERIZATION INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-01-30 | — | — | US | disclosed |
| EP-0990645-A1 | NOVEL SULFONAMIDE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-04-05 | — | — | EP | disclosed |