Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561679 | 0.90 | ALDH1A1 (0.49) | TDP1LMNAL3MBTL1ALDH1A1TP53 | |
| SCHEMBL6562122 | 0.88 | ALOX15 (0.54) | LMNAL3MBTL1ALDH1A1TP53HPGD | |
| SCHEMBL6563164 | 0.84 | ALDH1A1 (0.54) | TDP1LMNAL3MBTL1ALDH1A1TP53 | |
| SCHEMBL6561733 | 0.84 | TSHR (0.64) | LMNAL3MBTL1ALDH1A1TP53HPGD | |
| SCHEMBL27181010 | 0.80 | MAPT (0.59) | TDP1LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6561737 | 0.78 | KEAP1 (0.49) | TDP1LMNAL3MBTL1ALDH1A1TP53 | |
| SCHEMBL6563188 | 0.78 | KEAP1 (0.49) | LMNAL3MBTL1ALDH1A1TP53HPGD | |
| SCHEMBL6561650 | 0.78 | KEAP1 (0.53) | TDP1LMNAL3MBTL1ALDH1A1TP53 | |
| SCHEMBL6561743 | 0.77 | LMNA (0.53) | TDP1LMNAL3MBTL1ALDH1A1TP53 | |
| SCHEMBL6561774 | 0.76 | KEAP1 (0.53) | TDP1LMNAL3MBTL1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990645-B1 | NOVEL SULFONAMIDE DERIVATIVES | NIPPON KAYAKU KK (JP) | 2004-07-28 | — | — | EP | disclosed |
| US-6180796-B1 | TUBULIN POLYMERIZATION INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-01-30 | — | — | US | disclosed |
| EP-0990645-A1 | NOVEL SULFONAMIDE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-04-05 | — | — | EP | disclosed |