Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.61 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29666490 | 0.80 | SIGMAR1 (0.67) | SIGMAR1CNR2GAANR4A1NR4A2 | |
| SCHEMBL3626830 | 0.80 | SIGMAR1 (0.67) | SIGMAR1GAATSHRNR4A1NR4A2 | |
| SCHEMBL1614544 | 0.80 | SIGMAR1 (0.67) | SIGMAR1CNR2GAANR4A1NR4A2 | |
| SCHEMBL6560707 | 0.80 | ALDH1A1 (0.39) | SIGMAR1GAA | |
| SCHEMBL10943508 | 0.79 | SIGMAR1 (0.65) | SIGMAR1CNR2GAANR4A1NR4A2 | |
| SCHEMBL1839015 | 0.79 | SIGMAR1 (0.65) | SIGMAR1GAA | |
| SCHEMBL8150820 | 0.79 | SIGMAR1 (0.65) | SIGMAR1GAANR4A1NR4A2NR4A3 | |
| SCHEMBL11872011 | 0.79 | SIGMAR1 (0.65) | SIGMAR1CNR2GAANR4A1NR4A2 | |
| SCHEMBL28259034 | 0.79 | SIGMAR1 (0.65) | SIGMAR1CNR2GAANR4A1NR4A2 | |
| SCHEMBL6563222 | 0.77 | SIGMAR1 (0.45) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944581-A4 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | LILLY CO ELI (US) | 2004-09-08 | — | — | EP | disclosed |
| US-6069247-A | REACTING AN ACETYLENECARBOXY AMIDE AND AN ARYL OR HETEROCYCLYL HALIDE OR A GROUP ENHANCING THE ELECTROPHILICITY OF THE ATOM TO WHICH IT IS ATTACHED FOR DISPLACEMENT; USING A PALLADIUM COMPOUND CATALYST, A BASE AND AN ACID | ELI LILLY AND COMPANY (US) | 2000-05-30 | — | — | US | disclosed |
| EP-0944581-A1 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | ELI LILLY AND COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5917038-A | REACTING PROPIOLAMIDE WITH ACTIVATED AROMATIC RING IN THE PRESENCE OF A PALLADIUM CATALYST | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| WO-1998022429-A1 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | ELI LILLY AND COMPANY (US) | 1998-05-28 | — | — | WO | disclosed |