Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 13/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 11/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12550525 | 0.79 | ALDH1A1 (0.53) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| Benzene SCHEMBL28335658 | 0.78 | TRPM8 (0.50) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL1029152 | 0.78 | TRPM8 (0.50) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL5042970 | 0.78 | TSPO (0.53) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL2090213 | 0.78 | HSD17B1 (0.49) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL29674730 | 0.78 | TSPO (0.53) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL6561817 | 0.77 | SIGMAR1 (0.61) | SIGMAR1 | |
| SCHEMBL5932324 | 0.76 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL7815992 | 0.76 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL10943951 | 0.76 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944581-A4 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | LILLY CO ELI (US) | 2004-09-08 | — | — | EP | disclosed |
| US-6069247-A | REACTING AN ACETYLENECARBOXY AMIDE AND AN ARYL OR HETEROCYCLYL HALIDE OR A GROUP ENHANCING THE ELECTROPHILICITY OF THE ATOM TO WHICH IT IS ATTACHED FOR DISPLACEMENT; USING A PALLADIUM COMPOUND CATALYST, A BASE AND AN ACID | ELI LILLY AND COMPANY (US) | 2000-05-30 | — | — | US | disclosed |
| EP-0944581-A1 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | ELI LILLY AND COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5917038-A | REACTING PROPIOLAMIDE WITH ACTIVATED AROMATIC RING IN THE PRESENCE OF A PALLADIUM CATALYST | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| WO-1998022429-A1 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | ELI LILLY AND COMPANY (US) | 1998-05-28 | — | — | WO | disclosed |